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ENZYME

ENZYME entry: EC 1.1.1.145

Accepted Name
3beta-hydroxy-Delta(5)-steroid dehydrogenase
Alternative Name(s)
3beta-hydroxy-5-ene steroid dehydrogenase
progesterone reductase
Reaction catalysed
a 3beta-hydroxy-Delta(5)-steroid + NAD(+) <=> a 3-oxo-Delta(5)-steroid + H(+) + NADH
Comment(s)
Acts on 3beta-hydroxyandrost-5-en-17-one to form androst-4-ene-3,17- dione and on 3beta-hydroxypregn-5-en-20-one to form progesterone.
Cross-references
BRENDA1.1.1.145
EC2PDB1.1.1.145
ExplorEnz1.1.1.145
PRIAM enzyme-specific profiles1.1.1.145
KEGG Ligand Database for Enzyme Nomenclature1.1.1.145
IUBMB Enzyme Nomenclature1.1.1.145
IntEnz1.1.1.145
MEDLINEFind literature relating to 1.1.1.145
MetaCyc1.1.1.145
Rhea expert-curated reactions1.1.1.145
UniProtKB/Swiss-Prot
P14060, 3BHS1_HUMANP27365, 3BHS1_MACMUQ60555, 3BHS1_MESAU
P24815, 3BHS1_MOUSEP22071, 3BHS1_RATP26439, 3BHS2_HUMAN
Q64421, 3BHS2_MESAUP26149, 3BHS2_MOUSEP22072, 3BHS2_RAT
P26150, 3BHS3_MOUSEQ62878, 3BHS4_RATO35469, 3BHS6_MOUSE
P14893, 3BHS_BOVINQ5IFP1, 3BHS_CANLFQ67477, 3BHS_FOWPN
O46516, 3BHS_HORSEA0A7H0DNE2, 3BHS_MONPVP9WQP6, 3BHS_MYCTO
P9WQP7, 3BHS_MYCTUQ9N119, 3BHS_PIGO57245, 3BHS_VACCA
P21097, 3BHS_VACCCP26670, 3BHS_VACCWQ89187, 3BHS_VAR67
Q9XWF0, HSD3B_CAEEL

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