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ENZYME entry: EC 1.1.1.145

Accepted Name
3-beta-hydroxy-Delta(5)-steroid dehydrogenase.
Alternative Name(s)
3-beta-hydroxy-5-ene steroid dehydrogenase.
Progesterone reductase.
Reaction catalysed
A 3-beta-hydroxy-Delta(5)-steroid + NAD(+) <=> a 3-oxo-Delta(5)-steroid + NADH
Comment(s)
Acts on 3-beta-hydroxyandrost-5-en-17-one to form androst-4-ene-3,17- dione and on 3-beta-hydroxypregn-5-en-20-one to form progesterone.
Cross-references
BRENDA1.1.1.145
EC2PDB1.1.1.145
ExplorEnz1.1.1.145
PRIAM enzyme-specific profiles1.1.1.145
KEGG Ligand Database for Enzyme Nomenclature1.1.1.145
IUBMB Enzyme Nomenclature1.1.1.145
IntEnz1.1.1.145
MEDLINEFind literature relating to 1.1.1.145
MetaCyc1.1.1.145
Rhea expert-curated reactions1.1.1.145
UniProtKB/Swiss-Prot
P14060, 3BHS1_HUMAN;  P27365, 3BHS1_MACMU;  Q60555, 3BHS1_MESAU;  
P24815, 3BHS1_MOUSE;  P22071, 3BHS1_RAT;  P26439, 3BHS2_HUMAN;  
Q64421, 3BHS2_MESAU;  P26149, 3BHS2_MOUSE;  P22072, 3BHS2_RAT;  
P26150, 3BHS3_MOUSE;  Q62878, 3BHS4_RAT;  O35469, 3BHS6_MOUSE;  
P14893, 3BHS_BOVIN;  Q5IFP1, 3BHS_CANLF;  Q67477, 3BHS_FOWPN;  
O46516, 3BHS_HORSE;  P9WQP6, 3BHS_MYCTO;  P9WQP7, 3BHS_MYCTU;  
Q9N119, 3BHS_PIG;  O57245, 3BHS_VACCA;  P21097, 3BHS_VACCC;  
P26670, 3BHS_VACCW;  Q89187, 3BHS_VAR67;  Q9XWF0, HSD3B_CAEEL;  

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