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ENZYME entry: EC 1.1.1.149

Accepted Name
20alpha-hydroxysteroid dehydrogenase.
Reaction catalysed
  • (17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) <=> 17alpha-hydroxyprogesterone + H(+) + NADH
  • (17R,20S)-17,20-dihydroxypregn-4-en-3-one + NADP(+) <=> 17alpha-hydroxyprogesterone + H(+) + NADPH
Comment(s)
Re-specific with respect to NAD(P)(+) (cf. EC 1.1.1.62).
Cross-references
BRENDA1.1.1.149
EC2PDB1.1.1.149
ExplorEnz1.1.1.149
PRIAM enzyme-specific profiles1.1.1.149
KEGG Ligand Database for Enzyme Nomenclature1.1.1.149
IUBMB Enzyme Nomenclature1.1.1.149
IntEnz1.1.1.149
MEDLINEFind literature relating to 1.1.1.149
MetaCyc1.1.1.149
Rhea expert-curated reactions1.1.1.149
UniProtKB/Swiss-Prot
P35430, AHD2_TETPY;  Q04828, AK1C1_HUMAN;  Q95JH7, AK1C1_MACFA;  
Q95JH6, AK1C1_MACFU;  Q5REQ0, AK1C1_PONAB;  Q8K023, AKC1H_MOUSE;  
P51652, AKC1H_RAT;  P80508, PE2R_RABIT;  

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