ID 1.1.1.149 DE 20alpha-hydroxysteroid dehydrogenase. CA (1) (17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) = 17alpha- CA hydroxyprogesterone + H(+) + NADH. CA (2) (17R,20S)-17,20-dihydroxypregn-4-en-3-one + NADP(+) = 17alpha- CA hydroxyprogesterone + H(+) + NADPH. CC -!- Re-specific with respect to NAD(P)(+) (cf. EC 1.1.1.62). DR P35430, AHD2_TETPY ; Q04828, AK1C1_HUMAN; Q95JH7, AK1C1_MACFA; DR Q95JH6, AK1C1_MACFU; Q5REQ0, AK1C1_PONAB; Q8K023, AKC1H_MOUSE; DR P51652, AKC1H_RAT ; P80508, PE2R_RABIT ; //