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ENZYME entry: EC 1.1.1.159

Accepted Name
7alpha-hydroxysteroid dehydrogenase.
Reaction catalysed
cholate + NAD(+) <=> 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH
Comment(s)
  • Catalyzes the oxidation of the 7alpha-hydroxy group of bile acids and alcohols both in their free and conjugated forms.
  • The Bacteroides fragilis and Clostridium enzymes can also utilize NADP(+).
Cross-references
BRENDA1.1.1.159
EC2PDB1.1.1.159
ExplorEnz1.1.1.159
PRIAM enzyme-specific profiles1.1.1.159
KEGG Ligand Database for Enzyme Nomenclature1.1.1.159
IUBMB Enzyme Nomenclature1.1.1.159
IntEnz1.1.1.159
MEDLINEFind literature relating to 1.1.1.159
MetaCyc1.1.1.159
Rhea expert-curated reactions1.1.1.159
UniProtKB/Swiss-Prot
O02691, HCD2_BOVIN;  Q99714, HCD2_HUMAN;  O08756, HCD2_MOUSE;  
O70351, HCD2_RAT;  Q5LA59, HDHA_BACFN;  P0AET9, HDHA_ECO57;  
P0AET8, HDHA_ECOLI;  

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