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ENZYME

ENZYME entry: EC 1.1.1.176

PURL: https://purl.expasy.org/enzyme/EC/1.1.1.176
Accepted Name
12alpha-hydroxysteroid dehydrogenase
Reaction catalysed
cholate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADPH + H(+)
Comment(s)
  • Catalyzes the oxidation of the 12alpha-hydroxy group of bile acids, both in their free and conjugated form.
  • Also acts on bile alcohols.
Cross-references
Rhea expert-curated reactions1.1.1.176
ExplorEnz1.1.1.176
IUBMB Enzyme Nomenclature1.1.1.176
UniProtKB/Swiss-Prot
P21215, 12AH_CLOS4
BRENDA1.1.1.176
MetaCyc1.1.1.176
KEGG Ligand Database for Enzyme Nomenclature1.1.1.176
EC2PDB1.1.1.176
MEDLINEFind literature relating to 1.1.1.176

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