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ENZYME

ENZYME entry: EC 1.1.1.188

PURL: https://purl.expasy.org/enzyme/EC/1.1.1.188
Accepted Name
prostaglandin-F synthase
Alternative Name(s)
PGD2 11-ketoreductase
PGF synthetase
prostaglandin 11-ketoreductase
prostaglandin-D2 11-ketoreductase
prostaglandin-D2 11-reductase
prostaglandin-D2 ketoreductase
prostaglandin-F synthetase
Reaction catalysed
prostaglandin F2alpha + NADP(+) = prostaglandin D2 + NADPH + H(+)
Comment(s)
  • Reduces prostaglandin D2 and prostaglandin H2 to prostaglandin F2; prostaglandin D2 is not an intermediate in the reduction of prostaglandin H2.
  • Also catalyzes the reduction of a number of carbonyl compounds, such as 9,10-phenanthroquinone and 4-nitroacetophenone.
Cross-references
BRENDA1.1.1.188
EC2PDB1.1.1.188
ExplorEnz1.1.1.188
KEGG Ligand Database for Enzyme Nomenclature1.1.1.188
IUBMB Enzyme Nomenclature1.1.1.188
MEDLINEFind literature relating to 1.1.1.188
MetaCyc1.1.1.188
Rhea expert-curated reactions1.1.1.188
UniProtKB/Swiss-Prot
P05980, AK1C3_BOVINP42330, AK1C3_HUMANQ5R7C9, AK1C3_PONAB

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