A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.1.1.188
| Accepted Name |
|---|
| Prostaglandin-F synthase.
|
| Alternative Name(s) |
|---|
| PGD(2) 11-ketoreductase. |
| PGF synthetase. |
| Prostaglandin 11-ketoreductase. |
| Prostaglandin-D(2) 11-ketoreductase. |
| Prostaglandin-D(2) 11-reductase. |
| Prostaglandin-D(2) ketoreductase. |
| Prostaglandin-F synthetase. |
| Reaction catalysed |
|---|
| (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) <=> (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH |
| Comment(s) |
|---|
- Reduces prostaglandin D(2) and prostaglandin H(2) to prostaglandin
F(2); prostaglandin D(2) is not an intermediate in the reduction of
prostaglandin H(2).
- Also catalyzes the reduction of a number of carbonyl compounds, such
as 9,10-phenanthroquinone and 4-nitroacetophenone.
|
| Cross-references |
|---|
| PROSITE | PDOC00061 |
| BRENDA | 1.1.1.188 |
| EC2PDB | 1.1.1.188 |
| ExplorEnz | 1.1.1.188 |
| PRIAM enzyme-specific profiles | 1.1.1.188 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.188 |
| IUBMB Enzyme Nomenclature | 1.1.1.188 |
| IntEnz | 1.1.1.188 |
| MEDLINE | Find literature relating to 1.1.1.188 |
| MetaCyc | 1.1.1.188 |
| UniProtKB/Swiss-Prot |
|
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