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ENZYME entry: EC 1.1.1.188

Accepted Name
prostaglandin-F synthase.
Alternative Name(s)
PGD2 11-ketoreductase.
PGF synthetase.
prostaglandin 11-ketoreductase.
prostaglandin-D2 11-ketoreductase.
prostaglandin-D2 11-reductase.
prostaglandin-D2 ketoreductase.
prostaglandin-F synthetase.
Reaction catalysed
NADP(+) + prostaglandin F2alpha <=> H(+) + NADPH + prostaglandin D2
Comment(s)
  • Reduces prostaglandin D2 and prostaglandin H2 to prostaglandin F2; prostaglandin D2 is not an intermediate in the reduction of prostaglandin H2.
  • Also catalyzes the reduction of a number of carbonyl compounds, such as 9,10-phenanthroquinone and 4-nitroacetophenone.
Cross-references
BRENDA1.1.1.188
EC2PDB1.1.1.188
ExplorEnz1.1.1.188
PRIAM enzyme-specific profiles1.1.1.188
KEGG Ligand Database for Enzyme Nomenclature1.1.1.188
IUBMB Enzyme Nomenclature1.1.1.188
IntEnz1.1.1.188
MEDLINEFind literature relating to 1.1.1.188
MetaCyc1.1.1.188
Rhea expert-curated reactions1.1.1.188
UniProtKB/Swiss-Prot
P42330, AK1C3_HUMAN;  Q5R7C9, AK1C3_PONAB;  P05980, PGFS1_BOVIN;  
P52897, PGFS2_BOVIN;  

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