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ENZYME entry: EC 1.1.1.189

Accepted Name
Prostaglandin-E(2) 9-reductase.
Alternative Name(s)
9-keto-prostaglandin E(2) reductase.
9-ketoprostaglandin reductase.
PGE(2) 9-ketoreductase.
PGE(2) 9-oxoreductase.
Prostaglandin-E(2) 9-oxoreductase.
Prostaglandin-E2 9-reductase.
Reaction catalysed
(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) <=> (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH
Comment(s)
  • Reduces prostaglandin E(2) to prostaglandin F(2)-alpha.
  • A number of other 9-oxo- and 15-oxo-prostaglandin derivatives can also be reduced to the corresponding hydroxy compounds.
  • May be identical with EC 1.1.1.197.
Cross-references
PROSITEPDOC00060
BRENDA1.1.1.189
EC2PDB1.1.1.189
ExplorEnz1.1.1.189
PRIAM enzyme-specific profiles1.1.1.189
KEGG Ligand Database for Enzyme Nomenclature1.1.1.189
IUBMB Enzyme Nomenclature1.1.1.189
IntEnz1.1.1.189
MEDLINEFind literature relating to 1.1.1.189
MetaCyc1.1.1.189
UniProtKB/Swiss-Prot
Q3SZD7, CBR1_BOVIN;  P16152, CBR1_HUMAN;  Q8MI29, CBR1_MACFA;  
P48758, CBR1_MOUSE;  Q28960, CBR1_PIG;  Q5RCU5, CBR1_PONAB;  
P47844, CBR1_RABIT;  P47727, CBR1_RAT;  P80508, PE2R_RABIT;  

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