ENZYME entry: EC 1.1.1.189
Accepted Name |
Prostaglandin-E(2) 9-reductase.
|
Alternative Name(s) |
9-keto-prostaglandin E(2) reductase. |
9-ketoprostaglandin reductase. |
PGE(2) 9-ketoreductase. |
PGE(2) 9-oxoreductase. |
Prostaglandin-E(2) 9-oxoreductase. |
Prostaglandin-E2 9-reductase. |
Reaction catalysed |
(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) <=> (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH |
Comment(s) |
- Reduces prostaglandin E(2) to prostaglandin F(2)-alpha.
- A number of other 9-oxo- and 15-oxo-prostaglandin derivatives can
also be reduced to the corresponding hydroxy compounds.
- May be identical with EC 1.1.1.197.
|
Cross-references |
PROSITE | PDOC00060 |
BRENDA | 1.1.1.189 |
EC2PDB | 1.1.1.189 |
ExplorEnz | 1.1.1.189 |
PRIAM enzyme-specific profiles | 1.1.1.189 |
KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.189 |
IUBMB Enzyme Nomenclature | 1.1.1.189 |
IntEnz | 1.1.1.189 |
MEDLINE | Find literature relating to 1.1.1.189 |
MetaCyc | 1.1.1.189 |
Rhea expert-curated reactions | 1.1.1.189 |
UniProtKB/Swiss-Prot |
|
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