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ENZYME entry: EC 1.1.1.203

Accepted Name
Uronate dehydrogenase.
Alternative Name(s)
Uronic acid dehydrogenase.
Reaction catalysed
  • Beta-D-galacturonate + NAD(+) <=> D-galactaro-1,5-lactone + NADH
  • Beta-D-glucuronate + NAD(+) <=> D-glucaro-1,5-lactone + NADH
Cofactor(s)
Mg(2+).
Comment(s)
  • The enzyme, characterized from the bacterium Agrobacterium fabrum, participates in oxidative degradation pathways for galacturonate and glucuronate.
  • The enzyme can only accept the beta anomeric form of the substrate.
  • The 1,5 lactone product is rather stable at cytosolic pH and does not hydrolyze spontaneously at a substantial rate.
  • Formerly EC 1.2.1.35.
Cross-references
BRENDA1.1.1.203
EC2PDB1.1.1.203
ExplorEnz1.1.1.203
PRIAM enzyme-specific profiles1.1.1.203
KEGG Ligand Database for Enzyme Nomenclature1.1.1.203
IUBMB Enzyme Nomenclature1.1.1.203
IntEnz1.1.1.203
MEDLINEFind literature relating to 1.1.1.203
MetaCyc1.1.1.203
Rhea expert-curated reactions1.1.1.203
UniProtKB/Swiss-Prot
Q7CRQ0, URODH_AGRFC;  Q88NN6, URODH_PSEPK;  Q888H1, URODH_PSESM;  

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