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ENZYME

ENZYME entry: EC 1.1.1.203

PURL: https://purl.expasy.org/enzyme/EC/1.1.1.203
Accepted Name
uronate dehydrogenase
Alternative Name(s)
uronic acid dehydrogenase
Reaction catalysed
  • beta-D-galacturonate + NAD(+) = D-galactaro-1,5-lactone + NADH + H(+)
  • beta-D-glucuronate + NAD(+) = D-glucaro-1,5-lactone + NADH + H(+)
Comment(s)
  • The enzyme, characterized from the bacterium Agrobacterium fabrum, participates in oxidative degradation pathways for galacturonate and glucuronate.
  • The enzyme can only accept the beta anomeric form of the substrate.
  • The 1,5 lactone product is rather stable at cytosolic pH and does not hydrolyze spontaneously at a substantial rate.
  • Formerly EC 1.2.1.35.
Cross-references
BRENDA1.1.1.203
EC2PDB1.1.1.203
ExplorEnz1.1.1.203
KEGG Ligand Database for Enzyme Nomenclature1.1.1.203
IUBMB Enzyme Nomenclature1.1.1.203
MEDLINEFind literature relating to 1.1.1.203
MetaCyc1.1.1.203
Rhea expert-curated reactions1.1.1.203
UniProtKB/Swiss-Prot
Q7CRQ0, URODH_AGRFCQ88NN6, URODH_PSEPKQ888H1, URODH_PSESM

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