ID 1.1.1.206 DE tropinone reductase I. AN TR-I. AN tropine dehydrogenase. AN tropinone reductase. CA NADP(+) + tropine = H(+) + NADPH + tropinone. CC -!- Also oxidizes other tropan-3alpha-ols, but not the corresponding CC beta-derivatives. CC -!- Represents, along with EC 1.1.1.236, a branch point in tropane CC alkaloid metabolism. CC -!- Tropine (the product of EC 1.1.1.206) is incorporated into CC hyoscyamine and scopolamine whereas pseudotropine (the product of CC EC 1.1.1.236) is the first specific metabolite on the pathway to the CC calystegines. CC -!- Both enzymes are always found together in any given tropane-alkaloid- CC producing species, have a common substrate, tropinone, and are CC strictly stereospecific. DR A7DY56, TRN1_COCOF ; P50162, TRN1_DATST ; //