ID   1.1.1.218
DE   morphine 6-dehydrogenase.
AN   naloxone reductase.
CA   (1) morphine + NAD(+) = H(+) + morphinone + NADH.
CA   (2) morphine + NADP(+) = H(+) + morphinone + NADPH.
CC   -!- Also acts on some other alkaloids, including codeine, normorphine and
CC       ethylmorphine, but only very slowly on 7,8-saturated derivatives such
CC       as dihydromorphine and dihydrocodeine.
CC   -!- In the reverse direction, also reduces naloxone to the 6alpha-hydroxy
CC       analog.
CC   -!- Activated by 2-sulfanylethan-1-ol (2-mercaptoethanol).
DR   P82809, AK1CD_MESAU;  Q02198, MORA_PSEPU ;  P82810, MORA_RABIT ;
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