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ENZYME entry: EC 1.1.1.219

Accepted Name
dihydroflavanol 4-reductase.
Alternative Name(s)
dihydroflavonol 4-reductase.
dihydrokaempferol 4-reductase.
NADPH-dihydromyricetin reductase.
Reaction catalysed
a (2R,3S,4S)-leucoanthocyanidin + NADP(+) <=> a (2R,3R)-dihydroflavonol + H(+) + NADPH
Comment(s)
  • This plant enzyme, involved in the biosynthesis of anthocyanidins, is known to act on (+)-dihydrokaempferol, (+)-taxifolin, and (+)- dihydromyricetin, although some enzymes may act only on a subset of these compounds.
  • Each dihydroflavonol is reduced to the corresponding cis-flavan-3,4- diol.
  • NAD(+) can act instead of NADP(+), but more slowly.
Cross-references
BRENDA1.1.1.219
EC2PDB1.1.1.219
ExplorEnz1.1.1.219
PRIAM enzyme-specific profiles1.1.1.219
KEGG Ligand Database for Enzyme Nomenclature1.1.1.219
IUBMB Enzyme Nomenclature1.1.1.219
IntEnz1.1.1.219
MEDLINEFind literature relating to 1.1.1.219
MetaCyc1.1.1.219
Rhea expert-curated reactions1.1.1.219
UniProtKB/Swiss-Prot
P14721, DFRA_ANTMA;  P51102, DFRA_ARATH;  P51103, DFRA_CALCH;  
P51104, DFRA_DIACA;  P51105, DFRA_GERHY;  P51106, DFRA_HORVU;  
P51108, DFRA_MAIZE;  Q9XES5, DFRA_MALDO;  P51109, DFRA_MEDSA;  
P14720, DFRA_PETHY;  Q84KP0, DFRA_PYRCO;  P51107, DFRA_SOLLC;  
P73212, DFRA_SYNY3;  P51110, DFRA_VITVI;  

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