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ENZYME entry: EC 1.1.1.252

Accepted Name
Tetrahydroxynaphthalene reductase.
Alternative Name(s)
T4HN reductase.
Reaction catalysed
Scytalone + NADP(+) <=> 1,3,6,8-tetrahydroxynaphthalene + NADPH
Comment(s)
  • Reduces 1,3,6,8-tetrahydroxynaphthalene to scytalone and also reduces 1,3,8-trihydroxynaphthalene to vermelone.
  • Involved with EC 4.2.1.94 in the biosynthesis of melanin in pathogenic fungi.
  • Formerly EC 1.3.1.50.
Cross-references
PROSITEPDOC00060
BRENDA1.1.1.252
EC2PDB1.1.1.252
ExplorEnz1.1.1.252
PRIAM enzyme-specific profiles1.1.1.252
KEGG Ligand Database for Enzyme Nomenclature1.1.1.252
IUBMB Enzyme Nomenclature1.1.1.252
IntEnz1.1.1.252
MEDLINEFind literature relating to 1.1.1.252
MetaCyc1.1.1.252
Rhea expert-curated reactions1.1.1.252
UniProtKB/Swiss-Prot
W3XAA0, PFMAG_PESFW;  Q12634, T4HR_MAGO7;  F9XMW6, T4HR_ZYMTI;  

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