Expasy logo

ENZYME

ENZYME entry: EC 1.1.1.267

Accepted Name
1-deoxy-D-xylulose-5-phosphate reductoisomerase
Alternative Name(s)
1-deoxyxylulose-5-phosphate reductoisomerase
DXP-reductoisomerase
Reaction catalysed
2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH
Comment(s)
  • The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.
  • The mechanism has been shown to be a retroaldol/aldol reaction.
Cross-references
BRENDA1.1.1.267
EC2PDB1.1.1.267
ExplorEnz1.1.1.267
PRIAM enzyme-specific profiles1.1.1.267
KEGG Ligand Database for Enzyme Nomenclature1.1.1.267
IUBMB Enzyme Nomenclature1.1.1.267
IntEnz1.1.1.267
MEDLINEFind literature relating to 1.1.1.267
MetaCyc1.1.1.267
Rhea expert-curated reactions1.1.1.267
UniProtKB/Swiss-Prot
Q81N10, DXR1_BACANQ81B49, DXR1_BACCRQ638M6, DXR1_BACCZ
Q6HG59, DXR1_BACHKQ81WL4, DXR2_BACANQ819Y3, DXR2_BACCR
Q636K5, DXR2_BACCZQ6HEZ4, DXR2_BACHKB0CD21, DXR_ACAM1
A3DE52, DXR_ACET2Q6FCG9, DXR_ACIADB7H1U5, DXR_ACIB3
B7I9U9, DXR_ACIB5B2I325, DXR_ACIBCB0VMU8, DXR_ACIBS
A3M654, DXR_ACIBTB0V6F3, DXR_ACIBYB7J9P7, DXR_ACIF2
B5EQQ4, DXR_ACIF5A3MZC4, DXR_ACTP2B0BTR0, DXR_ACTPJ
A0KHG9, DXR_AERHHA4SQH6, DXR_AERS4B6JH72, DXR_AFIC5
C4ZA70, DXR_AGARVQ8UC86, DXR_AGRFCQ5E3E5, DXR_ALIF1
B5F9X0, DXR_ALIFMB6EK51, DXR_ALISLA8MHH5, DXR_ALKOO
B9JTP4, DXR_ALLAMB8J6S7, DXR_ANAD2B9KIT5, DXR_ANAMF
Q5PAI9, DXR_ANAMMQ2GKQ8, DXR_ANAPZB4UD63, DXR_ANASK
O66722, DXR_AQUAEQ9XFS9, DXR_ARATHQ5NZG9, DXR_AROAE
A0JUS3, DXR_ARTS2Q732P8, DXR_BACC1C1EP45, DXR_BACC3
B7HLF4, DXR_BACC7B9IVB0, DXR_BACCQQ5L9P6, DXR_BACFN
Q64PY9, DXR_BACFRQ65JJ3, DXR_BACLDA8FDB9, DXR_BACP2
O31753, DXR_BACSUQ8A684, DXR_BACTNA7Z4S6, DXR_BACVZ
Q1LSV3, DXR_BAUCHC5BWT4, DXR_BEUC1B3DQ62, DXR_BIFLD
Q8G7Y7, DXR_BIFLOB7GQ02, DXR_BIFLSQ7VRE2, DXR_BLOFL
Q493C8, DXR_BLOPBQ2L155, DXR_BORA1Q7WJ88, DXR_BORBR
Q7WA54, DXR_BORPAA9INU2, DXR_BORPDQ7VYC4, DXR_BORPE
Q89KP9, DXR_BRADUA5EK49, DXR_BRASBA4YVG0, DXR_BRASO
C0ZF60, DXR_BREBNB8D932, DXR_BUCA5P57329, DXR_BUCAI
Q8K9S7, DXR_BUCAPB8D7D6, DXR_BUCATB1YS68, DXR_BURA4
A0K8D7, DXR_BURCHB4ECM5, DXR_BURCJQ0BE21, DXR_BURCM
Q39F49, DXR_BURL3A9AIM0, DXR_BURM1A3MKT7, DXR_BURM7
A2SB78, DXR_BURM9Q62JD0, DXR_BURMAA1V563, DXR_BURMS
B1JUE4, DXR_BURO0Q1BHH6, DXR_BURO1A3NWM5, DXR_BURP0
Q3JR34, DXR_BURP1A3NAU2, DXR_BURP6Q63T18, DXR_BURPS
Q2SWZ2, DXR_BURTAA4JF69, DXR_BURVGQ8RA28, DXR_CALS4
A7H0K4, DXR_CAMC5A0RMI1, DXR_CAMFFA7HZP3, DXR_CAMHC
A8FN24, DXR_CAMJ8A7H243, DXR_CAMJDQ9PMV3, DXR_CAMJE
A1W0W2, DXR_CAMJJQ5HT65, DXR_CAMJRB9KE50, DXR_CAMLR
Q3AB86, DXR_CARHZQ9A709, DXR_CAUVCB8GWR7, DXR_CAUVN
B3PBQ4, DXR_CELJUA3PJG0, DXR_CERS1Q3J2X1, DXR_CERS4
A4WUH5, DXR_CERS5B9KRU3, DXR_CERSKQ5L651, DXR_CHLAB
Q3AUE4, DXR_CHLCHQ823G9, DXR_CHLCVQ254F0, DXR_CHLFF
B3EE57, DXR_CHLL2Q3B6R4, DXR_CHLL3Q9PKW8, DXR_CHLMU
B3EK13, DXR_CHLPBA1BJT7, DXR_CHLPDA4SCF3, DXR_CHLPM
Q9Z8J8, DXR_CHLPNB0B9H9, DXR_CHLT2B3QXY0, DXR_CHLT3
Q3KMV0, DXR_CHLTAB0BB58, DXR_CHLTBQ8KG43, DXR_CHLTE
O84074, DXR_CHLTRQ7NVY8, DXR_CHRVOB5EHV5, DXR_CITBB
Q97I58, DXR_CLOABA7FW01, DXR_CLOB1C3L0C4, DXR_CLOB6
A6LSP7, DXR_CLOB8B2V4G1, DXR_CLOBAB2TJ47, DXR_CLOBB
A5I4K2, DXR_CLOBHC1FS67, DXR_CLOBJB1II57, DXR_CLOBK
A7GG14, DXR_CLOBLB1KWL5, DXR_CLOBMQ185R8, DXR_CLOD6
B9E1J4, DXR_CLOK1A5N834, DXR_CLOK5A0Q0R4, DXR_CLONN
Q0TPQ9, DXR_CLOP1Q8XJR1, DXR_CLOPEQ0SSC6, DXR_CLOPS
Q895K5, DXR_CLOTEQ485G4, DXR_COLP3Q6NGL1, DXR_CORDI
Q8FP80, DXR_COREFA4QF22, DXR_CORGBQ8NP10, DXR_CORGL
Q4JV26, DXR_CORJKB1WNP5, DXR_CROS5Q1LNF2, DXR_CUPMC
Q0KA22, DXR_CUPNHQ470E3, DXR_CUPPJB3R2B1, DXR_CUPTR
Q6A7K8, DXR_CUTAKB8HVK1, DXR_CYAP4Q47F86, DXR_DECAR
Q9RU84, DXR_DEIRAB1I2I8, DXR_DESAPB8FR31, DXR_DESHD
Q24UG4, DXR_DESHYA8ZTM6, DXR_DESOHQ6AP35, DXR_DESPS
A4J5Y5, DXR_DESRMQ8X8Y1, DXR_ECO57P45568, DXR_ECOLI
C5BHC1, DXR_EDWI9Q3YRZ5, DXR_EHRCJQ2GGR4, DXR_EHRCR
Q5FHA4, DXR_EHRRGQ5HB55, DXR_EHRRWB2KCJ9, DXR_ELUMP
B1H060, DXR_ENDTXB2VE12, DXR_ERWT9B1YI70, DXR_EXIS2
C4L656, DXR_EXISAA7HLL7, DXR_FERNBQ14G49, DXR_FRAT1
A7NAP0, DXR_FRATFQ2A4P9, DXR_FRATHB2SFW7, DXR_FRATM
A0Q7Y5, DXR_FRATNQ0BN25, DXR_FRATOQ5NEP6, DXR_FRATT
A4IWJ1, DXR_FRATWQ8R622, DXR_FUSNNB9M5C0, DXR_GEODF
Q5L0J6, DXR_GEOKAQ39W82, DXR_GEOMGQ74BW4, DXR_GEOSL
C6E518, DXR_GEOSMC5D9C1, DXR_GEOSWA5G7W2, DXR_GEOUR
B8F4X2, DXR_GLAP5B7KAT5, DXR_GLOC7Q7NID1, DXR_GLOVI
Q5FPZ1, DXR_GLUOXQ7VM27, DXR_HAEDUQ4QM93, DXR_HAEI8
A5UDR7, DXR_HAEIEA5UHV9, DXR_HAEIGP44055, DXR_HAEIN
Q2SBQ3, DXR_HAHCHQ9KA69, DXR_HALH5B8CW61, DXR_HALOH
Q7VIT0, DXR_HELHPB0THN7, DXR_HELMIB6JKE8, DXR_HELP2
B5Z9Y5, DXR_HELPGQ1CUT8, DXR_HELPHQ9ZML6, DXR_HELPJ
B2US45, DXR_HELPSP56139, DXR_HELPYA4G4S7, DXR_HERAR
Q5QUF4, DXR_IDILOA6SZP5, DXR_JANMAQ28PJ0, DXR_JANSC
Q9AJD7, DXR_KITGRC4Z5K1, DXR_LACE2A9KMX2, DXR_LACP7
C1D9F0, DXR_LARHHQ1MRD4, DXR_LAWIPQ6AEY1, DXR_LEIXX
B0SDN1, DXR_LEPBAQ04U66, DXR_LEPBJQ053M9, DXR_LEPBL
B0SM60, DXR_LEPBPQ72U08, DXR_LEPICQ8F146, DXR_LEPIN
Q92C37, DXR_LISINC1L2M3, DXR_LISMCQ720A5, DXR_LISMF
B8DG10, DXR_LISMHQ8Y7G4, DXR_LISMOA0AIB8, DXR_LISW6
B1HQZ7, DXR_LYSSCB9EBE2, DXR_MACCJQ8EWQ6, DXR_MALP2
Q65R75, DXR_MANSMQ9XES0, DXR_MENPIQ60BA4, DXR_METCA
Q1H145, DXR_METFKB0JWW6, DXR_MICANQ2RJN4, DXR_MOOTA
A0QJ14, DXR_MYCA1P64013, DXR_MYCBOA1KML5, DXR_MYCBP
C1AFY6, DXR_MYCBTQ7NC17, DXR_MYCGAB8ZRU7, DXR_MYCLB
Q9CBU3, DXR_MYCLEB2HJP9, DXR_MYCMMQ73VS1, DXR_MYCPA
A0QVH7, DXR_MYCS2A5U6M4, DXR_MYCTAP9WNS0, DXR_MYCTO
P9WNS1, DXR_MYCTUA0PQ95, DXR_MYCUAB9L7Q2, DXR_NAUPA
Q5F5X0, DXR_NEIG1Q9JX33, DXR_NEIMAQ9K1G8, DXR_NEIMB
Q0AEI0, DXR_NITECQ82U01, DXR_NITEUQ1QMN1, DXR_NITHX
Q2YBA1, DXR_NITMUQ3JCW9, DXR_NITOCQ72DR3, DXR_NITV2
A1VFB6, DXR_NITV4Q3SRH8, DXR_NITWNQ5YS72, DXR_NOCFA
B2ITX3, DXR_NOSP7Q8YP49, DXR_NOSS1Q313H2, DXR_OLEA2
H8ZW44, DXR_ORIVUQ8W250, DXR_ORYSJA1R4Z8, DXR_PAEAT
A1B969, DXR_PARDPQ7U8C3, DXR_PARMWB2JIC0, DXR_PARP8
B2T5I8, DXR_PARPJQ6MEL5, DXR_PARUWQ13XC2, DXR_PARXL
P57985, DXR_PASMUQ6D8D9, DXR_PECASC6DAI7, DXR_PECCP
B4SAR7, DXR_PELPBA1AQN8, DXR_PELPDA5D2U3, DXR_PELTS
Q4FM64, DXR_PELUBC0QTC4, DXR_PERMHQ7N8P3, DXR_PHOLL
Q6LN30, DXR_PHOPRA6L0W8, DXR_PHOV8Q8IKG4, DXR_PLAF7
O96693, DXR_PLAFXB2RJX5, DXR_PORG3Q7MUW3, DXR_PORGI
B4S387, DXR_PROA2A2C3T8, DXR_PROM1A2BXK2, DXR_PROM5
Q319Z8, DXR_PROM9Q7VB62, DXR_PROMAB4F2C9, DXR_PROMH
Q7V6J8, DXR_PROMMQ7V0W0, DXR_PROMPQ46JT6, DXR_PROMT
Q48F65, DXR_PSE14A6V1D8, DXR_PSEA7B7V7G3, DXR_PSEA8
Q02RC2, DXR_PSEABQ9KGU6, DXR_PSEAEB8HFR2, DXR_PSECP
Q4KHH0, DXR_PSEF5C3K601, DXR_PSEFSA8F4Z0, DXR_PSELT
A4XWT5, DXR_PSEMYA5W844, DXR_PSEP1Q3KHA6, DXR_PSEPF
B0KSA5, DXR_PSEPGQ88MH4, DXR_PSEPKB1JBQ4, DXR_PSEPW
Q886N7, DXR_PSESMQ4ZWS2, DXR_PSEU2Q4FRH9, DXR_PSYA2
Q1QA16, DXR_PSYCKA1SYV7, DXR_PSYINA5WGE7, DXR_PSYWF
Q8XZI5, DXR_RALN1B2UB12, DXR_RALPJB3PQ37, DXR_RHIE6
Q2K3K0, DXR_RHIECQ1MB26, DXR_RHIJ3Q92LP6, DXR_RHIME
B9JBW0, DXR_RHIR8Q7URM5, DXR_RHOBAB6ISU5, DXR_RHOCS
Q0S275, DXR_RHOJRQ2IW86, DXR_RHOP2Q07NI7, DXR_RHOP5
Q6N5Q6, DXR_RHOPAQ215E3, DXR_RHOPBQ136B0, DXR_RHOPS
B3Q7J8, DXR_RHOPTB7K5G6, DXR_RIPO1Q5LSU9, DXR_RUEPO
Q1GGS3, DXR_RUESTB8I6D9, DXR_RUMCHA1AV71, DXR_RUTMC
Q21HH8, DXR_SACD2Q57T35, DXR_SALCHQ5PD59, DXR_SALPA
Q8Z9A6, DXR_SALTIQ8ZRP3, DXR_SALTYA8GIE2, DXR_SERP5
A1S4P6, DXR_SHEAMB8E7R0, DXR_SHEB2A3D2L1, DXR_SHEB5
A9KUL1, DXR_SHEB9Q085D6, DXR_SHEFNB0TP77, DXR_SHEHH
A3QG97, DXR_SHELPQ8EGG9, DXR_SHEONA8H6L0, DXR_SHEPA
B8CQ79, DXR_SHEPWA0KZ17, DXR_SHESAA8FY36, DXR_SHESH
Q0HGW1, DXR_SHESMQ0HT68, DXR_SHESRB1KNT7, DXR_SHEWM
Q83MD3, DXR_SHIFLQ5WFT4, DXR_SHOC1C3M9M8, DXR_SINFN
A6UDH9, DXR_SINMWQ2NRL1, DXR_SODGMQ01QM3, DXR_SOLUE
Q82K41, DXR_STRAWQ9KYS1, DXR_STRCOA4VJS7, DXR_STUS1
B2V847, DXR_SULSYQ67PA9, DXR_SYMTHQ31N26, DXR_SYNE7
Q2JXQ9, DXR_SYNJAQ2JM39, DXR_SYNJBQ9RCT1, DXR_SYNP6
Q0IBN9, DXR_SYNS3Q3AZ20, DXR_SYNS9Q3AI71, DXR_SYNSC
Q55663, DXR_SYNY3Q9WZZ1, DXR_THEMAB9KA80, DXR_THENN
A5IIP4, DXR_THEP1B0K9Q9, DXR_THEP3B0K1E5, DXR_THEPX
B9L006, DXR_THERPQ72KE2, DXR_THET2Q5SJZ6, DXR_THET8
Q8DK30, DXR_THEVBB5YI09, DXR_THEYDA0A1U9X9N3, DXR_THYVU
C4L858, DXR_TOLATQ73K78, DXR_TREDEO83610, DXR_TREPA
B3E7B0, DXR_TRIL1Q3MDL2, DXR_TRIV2Q83IC8, DXR_TROW8
Q83GY8, DXR_TROWTA5CY29, DXR_VESOHA7MXZ4, DXR_VIBC1
A5F615, DXR_VIBC3Q9KPV8, DXR_VIBCHC3LQ26, DXR_VIBCM
Q87ME3, DXR_VIBPAQ8DBF5, DXR_VIBVUQ7MIG6, DXR_VIBVY
Q8D2G6, DXR_WIGBRQ73GG3, DXR_WOLPMB3CN89, DXR_WOLPP
Q7M9M7, DXR_WOLSUQ5GTA4, DXR_WOLTRC0R414, DXR_WOLWR
Q8PML1, DXR_XANACQ4USQ4, DXR_XANC8B0RW72, DXR_XANCB
Q8PAV9, DXR_XANCPQ3BVL0, DXR_XANE5Q2P4B2, DXR_XANOM
B2SR05, DXR_XANOPQ5H1E7, DXR_XANORB2I7P4, DXR_XYLF2
Q9PEI0, DXR_XYLFAB0U242, DXR_XYLFMQ87EH9, DXR_XYLFT
A1JP78, DXR_YERE8A7FFH3, DXR_YERP3Q1CAN0, DXR_YERPA
B2JZ30, DXR_YERPBQ8ZH62, DXR_YERPEA9R392, DXR_YERPG
Q1CFF1, DXR_YERPNA4TL87, DXR_YERPPQ667J3, DXR_YERPS
B1JQG4, DXR_YERPYQ9X5F2, DXR_ZYMMO

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-