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ENZYME entry: EC 1.1.1.27

Accepted Name
L-lactate dehydrogenase
Alternative Name(s)
L-lactic acid dehydrogenase
L-lactic dehydrogenase
Reaction catalysed
(S)-lactate + NAD(+) <=> H(+) + NADH + pyruvate
Comment(s)
  • Also oxidizes other (S)-2-hydroxymonocarboxylic acids.
  • NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.
Cross-references
BRENDA1.1.1.27
EC2PDB1.1.1.27
ExplorEnz1.1.1.27
PRIAM enzyme-specific profiles1.1.1.27
KEGG Ligand Database for Enzyme Nomenclature1.1.1.27
IUBMB Enzyme Nomenclature1.1.1.27
IntEnz1.1.1.27
MEDLINEFind literature relating to 1.1.1.27
MetaCyc1.1.1.27
Rhea expert-curated reactions1.1.1.27
UniProtKB/Swiss-Prot
Q81RW4, LDH1_BACANP62047, LDH1_BACC1Q81EP4, LDH1_BACCR
Q63CN1, LDH1_BACCZQ6HK31, LDH1_BACHKE8MJ15, LDH1_BIFL2
P59050, LDH1_BIFLOQ97MD1, LDH1_CLOABQ839C1, LDH1_ENTFA
Q5FMB0, LDH1_LACACP62052, LDH1_LACJOQ01462, LDH1_LACLA
P04034, LDH1_LACLCP56512, LDH1_LACPLQ92F65, LDH1_LISIN
Q724K3, LDH1_LISMFP33380, LDH1_LISMOP14561, LDH1_PERPY
A7WXP7, LDH1_STAA1A6TY25, LDH1_STAA2Q2FK29, LDH1_STAA3
Q2G218, LDH1_STAA8A5IPA9, LDH1_STAA9Q2YV38, LDH1_STAAB
Q5HJD7, LDH1_STAACA6QDL6, LDH1_STAAEP65255, LDH1_STAAM
P65256, LDH1_STAANQ6GK73, LDH1_STAARQ6GCN4, LDH1_STAAS
A8Z0K3, LDH1_STAATP65257, LDH1_STAAWQ81K80, LDH2_BACAN
P62048, LDH2_BACC1Q816G3, LDH2_BACCRQ632G8, LDH2_BACCZ
Q6HC14, LDH2_BACHKE8ME30, LDH2_BIFL2P0CW93, LDH2_BIFLO
Q97DC6, LDH2_CLOABQ838C9, LDH2_ENTFAQ5FKK7, LDH2_LACAC
P62053, LDH2_LACJOQ9CII4, LDH2_LACLAP0C2T6, LDH2_LACLC
P59390, LDH2_LACPLQ92BI0, LDH2_LISINQ71ZD6, LDH2_LISMF
Q8Y6Z6, LDH2_LISMOP20619, LDH2_PERPYA7X6Y1, LDH2_STAA1
A6U4Y2, LDH2_STAA2Q2FDQ7, LDH2_STAA3Q2G1Y5, LDH2_STAA8
A5IW27, LDH2_STAA9Q2YWF6, LDH2_STAABQ5HCV0, LDH2_STAAC
A6QK89, LDH2_STAAEP65258, LDH2_STAAMP99119, LDH2_STAAN
Q6GDK1, LDH2_STAARQ6G674, LDH2_STAASP0C7U6, LDH2_STAAT
Q8NUM9, LDH2_STAAWQ81XJ7, LDH3_BACANP62049, LDH3_BACC1
Q815X8, LDH3_BACCRQ631X2, LDH3_BACCZQ6HBQ8, LDH3_BACHK
Q9CGG8, LDH3_LACLAQ6ZMR3, LDH6A_HUMANQ3T056, LDH6B_BOVIN
Q9BYZ2, LDH6B_HUMANQ4R816, LDH6B_MACFAQ9PW06, LDHA_ALLMI
Q9W7M6, LDHA_AMBMEA0A1F3, LDHA_BOSMUP19858, LDHA_BOVIN
Q98SL2, LDHA_CAICAP69080, LDHA_CHAACO93541, LDHA_CHAGU
P00340, LDHA_CHICKP69081, LDHA_CHIRAQ9PW07, LDHA_COLLI
Q9W7K5, LDHA_CYPCAQ9PVK5, LDHA_DANREQ9PW61, LDHA_DISEL
O93544, LDHA_DISMAO93542, LDHA_ELEMCQ92055, LDHA_FUNHE
P69083, LDHA_GILMIP69084, LDHA_GILSEO93540, LDHA_GOBGI
O93537, LDHA_HARANP22988, LDHA_HORVUP00338, LDHA_HUMAN
O93545, LDHA_LINNUQ9PW58, LDHA_LYCDAQ9BE24, LDHA_MACFA
Q9XT87, LDHA_MONDOP06151, LDHA_MOUSEP69085, LDHA_NOTAN
O93539, LDHA_NOTNEP69086, LDHA_PAGBOQ5R1W9, LDHA_PANTR
O93538, LDHA_PARCRO93543, LDHA_PARMGO93546, LDHA_PATTE
Q98SL0, LDHA_PELSJP00339, LDHA_PIGQ5R5F0, LDHA_PONAB
Q9W7L3, LDHA_PYTRGP13491, LDHA_RABITP04642, LDHA_RAT
O93401, LDHA_RHINCQ9P4B6, LDHA_RHIORQ9W7L5, LDHA_SCEUN
P79912, LDHA_SCEWOO13276, LDHA_SPHAGO13277, LDHA_SPHID
O13278, LDHA_SPHLUP00341, LDHA_SQUACQ9PT43, LDHA_TRASE
P69082, LDHA_TREBEP42120, LDHA_XENLAQ9PVK4, LDHBA_DANRE
Q6DGK2, LDHBB_DANREQ9PW05, LDHB_ALLMIP13743, LDHB_ANAPL
Q9YGL2, LDHB_ANGROQ5E9B1, LDHB_BOVINQ98SL1, LDHB_CAICA
P00337, LDHB_CHICKQ9PW04, LDHB_COLLIP20373, LDHB_FUNHE
P42122, LDHB_FUNPAP22989, LDHB_HORVUP07195, LDHB_HUMAN
Q4R5B6, LDHB_MACFAQ9XT86, LDHB_MONDOP16125, LDHB_MOUSE
A5A6N7, LDHB_PANTRQ98SK9, LDHB_PELSJP00336, LDHB_PIG
Q1EG91, LDHB_POLSEP13490, LDHB_RABITP42123, LDHB_RAT
Q9P4B5, LDHB_RHIORQ9W7L4, LDHB_SCEUNP79913, LDHB_SCEWO
Q9YI05, LDHB_SQUACQ9PT42, LDHB_TRASEP42119, LDHB_XENLA
Q06176, LDHC_FUNHEP07864, LDHC_HUMANP00342, LDHC_MOUSE
Q9TSX5, LDHC_PIGP19629, LDHC_RATQ29563, LDHC_VULVU
P42121, LDHC_XENLAQ8KQC4, LDH_ACET2B9JTR0, LDH_ALLAM
P10655, LDH_BACCAQ59244, LDH_BACCLQ65NP0, LDH_BACLD
A8F9Q8, LDH_BACP2P13714, LDH_BACSUA7Z152, LDH_BACVZ
B8DSV5, LDH_BIFA0Q0SP77, LDH_BORAPO51114, LDH_BORBU
B7J121, LDH_BORBZQ662S5, LDH_BORGPB2S1S1, LDH_BORHD
A1QYN6, LDH_BORT9P93052, LDH_BOTBRQ27888, LDH_CAEEL
B3QX21, LDH_CHLT3A7FU32, LDH_CLOB1C3KVF0, LDH_CLOB6
A5I1Z6, LDH_CLOBHC1FMZ1, LDH_CLOBJB1IKX1, LDH_CLOBK
A7GDK3, LDH_CLOBLB1L1N3, LDH_CLOBMQ0TUX8, LDH_CLOP1
Q8XP62, LDH_CLOPEQ0SWR1, LDH_CLOPSQ892U0, LDH_CLOTE
P62050, LDH_CORDIQ8FLV6, LDH_COREFA4QHW5, LDH_CORGB
Q8NLN0, LDH_CORGLQ4JY42, LDH_CORJKQ07251, LDH_CUPNH
Q6A9C3, LDH_CUTAKP50933, LDH_DEIRAA4J898, LDH_DESRM
P62051, LDH_DESVHA1VG02, LDH_DESVVQ95028, LDH_DROME
A7HM89, LDH_FERNBQ8RED8, LDH_FUSNNB9LZ61, LDH_GEODF
Q5L2S0, LDH_GEOKAP00344, LDH_GEOSEC5D5V2, LDH_GEOSW
A4IKL5, LDH_GEOTNQ7NG49, LDH_GLOVIQ9K5Z8, LDH_HALH5
C5CGP2, LDH_KOSOTP00343, LDH_LACCAQ04CN9, LDH_LACDB
O32765, LDH_LACHEP0CI34, LDH_LACLMD8KFT1, LDH_LACLN
P56511, LDH_LACPEP50934, LDH_LATSKQ38V71, LDH_LATSS
Q1WSG2, LDH_LIGS1B2GBW0, LDH_LIMF3Q8GMJ0, LDH_LIMRT
B9E9F9, LDH_MACCJP29038, LDH_MAIZEQ8EUG3, LDH_MALP2
Q6F0L9, LDH_MESFLP0C0J2, LDH_MESH2Q4A8M8, LDH_MESH7
P0C0J3, LDH_MESHJP0C0J4, LDH_MESHOQ6KIP9, LDH_MESM1
Q2RHG3, LDH_MOOTAQ2SS50, LDH_MYCCTO52354, LDH_MYCGA
P47698, LDH_MYCGEP62054, LDH_MYCMSP78007, LDH_MYCPN
Q98PG4, LDH_MYCPUQ8ELF0, LDH_OCEIHQ59645, LDH_PEDAC
Q03DZ7, LDH_PEDPAP33571, LDH_PETMAA9BGZ9, LDH_PETMO
Q7SI97, LDH_PLABAP84793, LDH_PLABEP13774, LDH_PLAFA
Q27743, LDH_PLAFDP00345, LDH_PRIMGA8F6M1, LDH_PSELT
Q2S4R2, LDH_SALRDQ9P7P7, LDH_SCHPOQ9EVR0, LDH_SELRU
Q5WE04, LDH_SHOC1B9DN51, LDH_STACTQ5HL31, LDH_STAEQ
Q8CMZ0, LDH_STAESQ4L941, LDH_STAHJQ49YJ3, LDH_STAS1
Q3K1C8, LDH_STRA1Q8E5N4, LDH_STRA3Q8DZY3, LDH_STRA5
C0M7H8, LDH_STRE4Q59828, LDH_STREIB4U309, LDH_STREM
A8AXK9, LDH_STRGCP26283, LDH_STRMUP65259, LDH_STRP1
Q04K99, LDH_STRP2P0DC18, LDH_STRP3B5E4V6, LDH_STRP4
Q5XC59, LDH_STRP6C1C7I6, LDH_STRP7P65261, LDH_STRP8
Q1JBQ9, LDH_STRPBQ1JLP1, LDH_STRPCQ1JGU2, LDH_STRPD
Q1J6L1, LDH_STRPFA2REG9, LDH_STRPGB1IC17, LDH_STRPI
B8ZQ84, LDH_STRPJQ48TK0, LDH_STRPMP0A3M9, LDH_STRPN
P0DC19, LDH_STRPQB5XLJ8, LDH_STRPZP0A3N0, LDH_STRR6
A4W1K6, LDH_STRS2C0MFB5, LDH_STRS7A3CN70, LDH_STRSV
A4VVA3, LDH_STRSYQ5LZ83, LDH_STRT1Q5M3T6, LDH_STRT2
Q03K30, LDH_STRTDQ60009, LDH_STRTRB9DS53, LDH_STRU0
C1CEH8, LDH_STRZJC1CKW1, LDH_STRZPC1CR83, LDH_STRZT
Q2JRH2, LDH_SYNJAQ2JJQ1, LDH_SYNJBP13715, LDH_THEAQ
P06150, LDH_THECAP16115, LDH_THEMAA5IL75, LDH_THEP1
B0KDA4, LDH_THEP3B0K226, LDH_THEPXB1LAF5, LDH_THESQ
Q7X5C9, LDH_THESWP62055, LDH_THET2Q5SJA1, LDH_THET8
Q27797, LDH_TOXGOP62056, LDH_TREDE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-