ID 1.1.1.272 DE D-2-hydroxyacid dehydrogenase (NADP(+)). CA a (2R)-2-hydroxycarboxylate + NADP(+) = a 2-oxocarboxylate + H(+) + CA NADPH. CC -!- This enzyme, characterized from the halophilic archaeon Haloferax CC mediterranei and the mold Aspergillus oryzae, catalyzes a reversible CC stereospecific reduction of 2-oxocarboxylic acids into the CC corresponding D-2-hydroxycarboxylic acids. CC -!- The enzyme prefers substrates with a main chain of 5 carbons (such as CC 4-methyl-2-oxopentanoate) to those with a shorter chain, and can use CC NADH with much lower efficiency. cf. EC 1.1.1.345. DR Q2UH56, HADHA_ASPOR; Q2U0N3, MORA_ASPOR ; //