ID   1.1.1.286
DE   isocitrate--homoisocitrate dehydrogenase.
AN   homoisocitrate--isocitrate dehydrogenase.
CA   (1) D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH.
CA   (2) (2R,3S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH.
CC   -!- Unlike EC 1.1.1.41 and EC 1.1.1.87, this enzyme, from Pyrococcus
CC       horikoshii, can use both isocitrate and homoisocitrate as substrate.
CC   -!- May play a role in both the lysine and glutamate biosynthesis
CC       pathways.
DR   O59394, HICDH_PYRHO;  Q72IW9, HICDH_THET2;  Q5SIJ1, HICDH_THET8;
//