ID 1.1.1.299 DE malate dehydrogenase [NAD(P)(+)]. CA (1) (S)-malate + NAD(+) = H(+) + NADH + oxaloacetate. CA (2) (S)-malate + NADP(+) = H(+) + NADPH + oxaloacetate. CC -!- This enzyme, which was characterized from the methanogenic archaeon CC Methanobacterium thermoautotrophicum, catalyzes only the reduction of CC oxaloacetate, and can use NAD(+) and NADP(+) with similar specific CC activity. CC -!- Different from EC 1.1.1.37, EC 1.1.1.82 and EC 1.1.5.4. DR Q9YEA1, MDH_AERPE ; Q8TWG5, MDH_METKA ; Q6LZI3, MDH_METMP ; DR Q2NGI3, MDH_METST ; O26290, MDH_METTH ; D9PVI7, MDH_METTM ; //