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ENZYME entry: EC 1.1.1.302

Accepted Name
2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase.
Alternative Name(s)
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase.
Reaction catalysed
  • 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) <=> 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADH
  • 2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) <=> 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + H(+) + NADPH
Comment(s)
  • The reaction proceeds in the opposite direction.
  • A step in riboflavin biosynthesis, NADPH and NADH function equally well as reductant.
  • Differs from EC 1.1.1.193 since it does not catalyze the reduction of 5-amino-6-ribosylaminopyrimidine-2,4(1H,3H)-dione 5'-phosphate.
Cross-references
BRENDA1.1.1.302
EC2PDB1.1.1.302
ExplorEnz1.1.1.302
PRIAM enzyme-specific profiles1.1.1.302
KEGG Ligand Database for Enzyme Nomenclature1.1.1.302
IUBMB Enzyme Nomenclature1.1.1.302
IntEnz1.1.1.302
MEDLINEFind literature relating to 1.1.1.302
MetaCyc1.1.1.302
Rhea expert-curated reactions1.1.1.302
UniProtKB/Swiss-Prot
O66747, RIB7_AQUAE;  O28272, RIB7_ARCFU;  Q757H6, RIB7_ASHGO;  
Q6FU96, RIB7_CANGA;  Q6BII9, RIB7_DEBHA;  Q6CJ61, RIB7_KLULA;  
Q9P4B8, RIB7_KLUMA;  Q58085, RIB7_METJA;  O26337, RIB7_METTH;  
P95872, RIB7_SACS2;  Q9P7L3, RIB7_SCHPO;  P33312, RIB7_YEAST;  

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