ENZYME entry: EC 1.1.1.312
Accepted Name |
2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase.
|
Alternative Name(s) |
4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase. |
Reaction catalysed |
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) <=> 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH |
Comment(s) |
- The enzyme does not act on unsubstituted aliphatic or aromatic
aldehydes or glucose; NAD(+) can replace NADP(+), but with lower
affinity.
- The enzyme was initially believed to act on 4-carboxy-2-hydroxy-
cis,cis-muconate 6-semialdehyde and produce 4-carboxy-2-hydroxy-
cis,cis-muconate.
- However, later studies showed that the substrate is the hemiacetal
form, and the product is 2-oxo-2H-pyran-4,6-dicarboxylate.
- Formerly EC 1.2.1.45.
|
Cross-references |
BRENDA | 1.1.1.312 |
EC2PDB | 1.1.1.312 |
ExplorEnz | 1.1.1.312 |
PRIAM enzyme-specific profiles | 1.1.1.312 |
KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.312 |
IUBMB Enzyme Nomenclature | 1.1.1.312 |
IntEnz | 1.1.1.312 |
MEDLINE | Find literature relating to 1.1.1.312 |
MetaCyc | 1.1.1.312 |
Rhea expert-curated reactions | 1.1.1.312 |
UniProtKB/Swiss-Prot |
|
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