ENZYME entry: EC 18.104.22.1682
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|2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase.
|4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) <=> 2-oxo-2H-pyran-4,6-dicarboxylate + NADPH|
- The enzyme does not act on unsubstituted aliphatic or aromatic
aldehydes or glucose; NAD(+) can replace NADP(+), but with lower
- The enzyme was initially believed to act on 4-carboxy-2-hydroxy-
cis,cis-muconate 6-semialdehyde and produce 4-carboxy-2-hydroxy-
- However, later studies showed that the substrate is the hemiacetal
form, and the product is 2-oxo-2H-pyran-4,6-dicarboxylate.
- Formerly EC 22.214.171.124.
|PRIAM enzyme-specific profiles||126.96.36.1992|
|KEGG Ligand Database for Enzyme Nomenclature||188.8.131.522|
|IUBMB Enzyme Nomenclature||184.108.40.2062|
|MEDLINE||Find literature relating to 220.127.116.112|
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