ENZYME

ENZYME entry: EC 1.1.1.312

Accepted Name

2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase.

Alternative Name(s)

4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase.

Reaction catalysed

4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) <=> 2-oxo-2H-pyran-4,6-dicarboxylate + NADPH

Comment(s)

The enzyme does not act on unsubstituted aliphatic or aromatic aldehydes or glucose; NAD(+) can replace NADP(+), but with lower affinity.
The enzyme was initially believed to act on 4-carboxy-2-hydroxy- cis,cis-muconate 6-semialdehyde and produce 4-carboxy-2-hydroxy- cis,cis-muconate.
However, later studies showed that the substrate is the hemiacetal form, and the product is 2-oxo-2H-pyran-4,6-dicarboxylate.
Formerly EC 1.2.1.45.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature