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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase.
Alternative Name(s)
4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase.
Reaction catalysed
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) <=> 2-oxo-2H-pyran-4,6-dicarboxylate + NADPH
  • The enzyme does not act on unsubstituted aliphatic or aromatic aldehydes or glucose; NAD(+) can replace NADP(+), but with lower affinity.
  • The enzyme was initially believed to act on 4-carboxy-2-hydroxy- cis,cis-muconate 6-semialdehyde and produce 4-carboxy-2-hydroxy- cis,cis-muconate.
  • However, later studies showed that the substrate is the hemiacetal form, and the product is 2-oxo-2H-pyran-4,6-dicarboxylate.
  • Formerly EC
PRIAM enzyme-specific profiles1.1.1.312
KEGG Ligand Database for Enzyme Nomenclature1.1.1.312
IUBMB Enzyme Nomenclature1.1.1.312
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
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