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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.1.1.312
| Accepted Name |
|---|
| 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase.
|
| Alternative Name(s) |
|---|
| 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase. |
| Reaction catalysed |
|---|
| 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) <=> 2-oxo-2H-pyran-4,6-dicarboxylate + NADPH |
| Comment(s) |
|---|
- The enzyme does not act on unsubstituted aliphatic or aromatic
aldehydes or glucose; NAD(+) can replace NADP(+), but with lower
affinity.
- The enzyme was initially believed to act on 4-carboxy-2-hydroxy-
cis,cis-muconate 6-semialdehyde and produce 4-carboxy-2-hydroxy-
cis,cis-muconate.
- However, later studies showed that the substrate is the hemiacetal
form, and the product is 2-oxo-2H-pyran-4,6-dicarboxylate.
- Formerly EC 1.2.1.45.
|
| Cross-references |
|---|
| BRENDA | 1.1.1.312 |
| EC2PDB | 1.1.1.312 |
| ExplorEnz | 1.1.1.312 |
| PRIAM enzyme-specific profiles | 1.1.1.312 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.312 |
| IUBMB Enzyme Nomenclature | 1.1.1.312 |
| IntEnz | 1.1.1.312 |
| MEDLINE | Find literature relating to 1.1.1.312 |
| MetaCyc | 1.1.1.312 |
| UniProtKB/Swiss-Prot |
|
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UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-