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ENZYME entry: EC 1.1.1.312

Accepted Name
2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase.
Alternative Name(s)
4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase.
Reaction catalysed
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) <=> 2-oxo-2H-pyran-4,6-dicarboxylate + NADPH
Comment(s)
  • The enzyme does not act on unsubstituted aliphatic or aromatic aldehydes or glucose; NAD(+) can replace NADP(+), but with lower affinity.
  • The enzyme was initially believed to act on 4-carboxy-2-hydroxy- cis,cis-muconate 6-semialdehyde and produce 4-carboxy-2-hydroxy- cis,cis-muconate.
  • However, later studies showed that the substrate is the hemiacetal form, and the product is 2-oxo-2H-pyran-4,6-dicarboxylate.
  • Formerly EC 1.2.1.45.
Cross-references
BRENDA1.1.1.312
EC2PDB1.1.1.312
ExplorEnz1.1.1.312
PRIAM enzyme-specific profiles1.1.1.312
KEGG Ligand Database for Enzyme Nomenclature1.1.1.312
IUBMB Enzyme Nomenclature1.1.1.312
IntEnz1.1.1.312
MEDLINEFind literature relating to 1.1.1.312
MetaCyc1.1.1.312
UniProtKB/Swiss-Prot
Q9KWL3, LIGC_SPHSK

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