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ENZYME entry: EC 1.1.1.315

Accepted Name
11-cis-retinol dehydrogenase.
Reaction catalysed
11-cis-retinol--[retinol-binding protein] + NAD(+) <=> 11-cis-retinal--[retinol-binding protein] + H(+) + NADH
Comment(s)
  • This enzyme, abundant in the retinal pigment epithelium, catalyzes the reduction of 11-cis-retinol to 11-cis-retinal while the substrate is bound to the retinal-binding protein.
  • This is a crucial step in the regeneration of 11-cis-retinal, the chromophore of rhodopsin.
  • The enzyme can also accept other cis forms of retinol.
Cross-references
BRENDA1.1.1.315
EC2PDB1.1.1.315
ExplorEnz1.1.1.315
PRIAM enzyme-specific profiles1.1.1.315
KEGG Ligand Database for Enzyme Nomenclature1.1.1.315
IUBMB Enzyme Nomenclature1.1.1.315
IntEnz1.1.1.315
MEDLINEFind literature relating to 1.1.1.315
MetaCyc1.1.1.315
Rhea expert-curated reactions1.1.1.315
UniProtKB/Swiss-Prot
O75452, RDH16_HUMAN;  O54909, RDH16_MOUSE;  P50170, RDH16_RAT;  
Q27979, RDH5_BOVIN;  Q92781, RDH5_HUMAN;  O55240, RDH5_MOUSE;  

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