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ENZYME entry: EC

Accepted Name
nicotine blue oxidoreductase.
Reaction catalysed
  • 3,3'-bipyridine-2,2',5,5',6,6'-hexol + NADP(+) <=> (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADPH
  • 3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(+) <=> (E)-2,2',5,5'-tetrahydroxy-6H,6'H-(3,3'-bipyridinylidene)-6,6'-dione + 3 H(+) + NADH
  • The enzyme, characterized from the nicotine degrading bacterium Arthrobacter nicotinovorans, catalyzes the reduction of 'nicotine blue' to its hydroquinone form (the opposite direction from that shown).
  • Nicotine blue is the name given to the compound formed by the autocatalytic condensation of two molecules of 2,3,6- trihydroxypyridine, an intermediate in the nicotine degradation pathway.
  • The main role of the enzyme may be to prevent the intracellular formation of nicotine blue semiquinone radicals, which by redox cycling would lead to the formation of toxic reactive oxygen species.
  • The enzyme possesses a slight preference for NADH over NADPH.
PRIAM enzyme-specific profiles1.1.1.328
KEGG Ligand Database for Enzyme Nomenclature1.1.1.328
IUBMB Enzyme Nomenclature1.1.1.328
MEDLINEFind literature relating to
Rhea expert-curated reactions1.1.1.328

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