ID 1.1.1.334 DE methylecgonone reductase. CA ecgonine methyl ester + NADP(+) = ecgonone methyl ester + NADPH + H(+). CC -!- The enzyme from the plant Erythroxylum coca catalyzes the penultimate CC step in the biosynthesis of cocaine. CC -!- In vivo the reaction proceeds in the opposite direction. CC -!- With NADH instead of NADPH the reaction rate is reduced to 14%. CC -!- The enzyme also reduces tropinone, nortropinone and CC 6-hydroxytropinone but with lower reaction rates. DR A0A9E8M491, MECGR_ERYNO; E7C196, MER_ERYCB ; //