ID   1.1.1.335
DE   UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase.
CA   NAD(+) + UDP-N-2-acetamido-2-deoxy-alpha-D-glucuronate = H(+) + NADH +
CA   UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate.
CC   -!- This enzyme participates in the biosynthetic pathway for UDP-alpha-D-
CC       ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic
CC       acid), an important precursor of B-band lipopolysaccharide.
CC   -!- The enzymes from Pseudomonas aeruginosa serotype O5 and Thermus
CC       thermophilus form a complex with the the enzyme catalyzing the next
CC       step the pathway (EC 2.6.1.98).
CC   -!- The enzyme also possesses an EC 1.1.99.2 activity, and utilizes the
CC       2-oxoglutarate produced by EC 2.6.1.98 to regenerate the tightly
CC       bound NAD(+).
CC   -!- The enzymes from Bordetella pertussis and Chromobacterium violaceum
CC       do not bind NAD(+) as tightly and do not require 2-oxoglutarate to
CC       function.
DR   G3XD23, WBPB_PSEAE ;
//