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ENZYME entry: EC 1.1.1.337

Accepted Name
L-2-hydroxycarboxylate dehydrogenase (NAD(+)).
Alternative Name(s)
(R)-sulfolactate dehydrogenase.
L-2-hydroxyacid dehydrogenase (NAD(+)).
L-sulfolactate dehydrogenase.
Reaction catalysed
a (2S)-2-hydroxycarboxylate + NAD(+) <=> a 2-oxocarboxylate + H(+) + NADH
Comment(s)
  • The enzyme from the archaeon Methanocaldococcus jannaschii acts on multiple L-2-hydroxycarboxylates including (2R)-3-sulfolactate, (S)- malate, (S)-lactate, and (S)-2-hydroxyglutarate.
  • Note that (2R)-3-sulfolactate has the same stereo configuration as (2S)-2-hydroxycarboxylates.
Cross-references
BRENDA1.1.1.337
EC2PDB1.1.1.337
ExplorEnz1.1.1.337
PRIAM enzyme-specific profiles1.1.1.337
KEGG Ligand Database for Enzyme Nomenclature1.1.1.337
IUBMB Enzyme Nomenclature1.1.1.337
IntEnz1.1.1.337
MEDLINEFind literature relating to 1.1.1.337
MetaCyc1.1.1.337
Rhea expert-curated reactions1.1.1.337
UniProtKB/Swiss-Prot
Q58820, COMC_METJA;  O27273, COMC_METTH;  

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