ID   1.1.1.345
DE   D-2-hydroxyacid dehydrogenase (NAD(+)).
AN   (R)-2-hydroxyisocaproate dehydrogenase.
AN   D-2-hydroxyisocaproate dehydrogenase.
CA   a (2R)-2-hydroxycarboxylate + NAD(+) = a 2-oxocarboxylate + H(+) + NADH.
CC   -!- The enzymes, characterized from bacteria (Peptoclostridium difficile,
CC       Enterococcus faecalis and from lactic acid bacteria) prefer
CC       substrates with a main chain of 5 carbons (such as 4-methyl-2-
CC       oxopentanoate) to those with a shorter chain.
CC   -!- It also utilizes phenylpyruvate.
CC   -!- The enzyme from the halophilic archaeon Haloferax mediterranei
CC       prefers substrates with a main chain of 3-4 carbons (pyruvate and
CC       2-oxobutanoate). cf. EC 1.1.1.272.
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