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ENZYME

ENZYME entry: EC 1.1.1.35

Accepted Name
3-hydroxyacyl-CoA dehydrogenase
Alternative Name(s)
beta-hydroxyacyl dehydrogenase
beta-keto-reductase
Reaction catalysed
a (3S)-3-hydroxyacyl-CoA + NAD(+) <=> a 3-oxoacyl-CoA + H(+) + NADH
Comment(s)
  • Also oxidizes S-3-hydroxyacyl-N-acylthioethanolamine and S-3- hydroxyacylhydrolipoate.
  • Some enzymes act, more slowly, with NADP(+).
  • Broad specificity to acyl chain-length (cf. EC 1.1.1.211).
Cross-references
BRENDA1.1.1.35
EC2PDB1.1.1.35
ExplorEnz1.1.1.35
PRIAM enzyme-specific profiles1.1.1.35
KEGG Ligand Database for Enzyme Nomenclature1.1.1.35
IUBMB Enzyme Nomenclature1.1.1.35
IntEnz1.1.1.35
MEDLINEFind literature relating to 1.1.1.35
MetaCyc1.1.1.35
Rhea expert-curated reactions1.1.1.35
UniProtKB/Swiss-Prot
Q9ZPI6, AIM1_ARATHP55100, ECHP_CAVPOQ6NYL3, ECHP_DANRE
Q08426, ECHP_HUMANQ9DBM2, ECHP_MOUSEQ5R5M8, ECHP_PONAB
P07896, ECHP_RATQ4UL32, FAD3_RICFEQ9ZCZ1, FAD3_RICPR
Q68WH7, FAD3_RICTYQ6FF68, FADB_ACIADB7H1I0, FADB_ACIB3
B7I3P1, FADB_ACIB5B2I2J9, FADB_ACIBCB0VLX4, FADB_ACIBS
B0VE45, FADB_ACIBYA0KEL1, FADB_AERHHA4STF2, FADB_AERS4
Q5E8X6, FADB_ALIF1B5FEW8, FADB_ALIFMB6EGU2, FADB_ALISL
A8ACZ4, FADB_CITK8Q489W3, FADB_COLP3A7MQP0, FADB_CROS8
A7ZU51, FADB_ECO24B7UNH4, FADB_ECO27B7MHD1, FADB_ECO45
B7L9A7, FADB_ECO55Q8X8I2, FADB_ECO57B5YY93, FADB_ECO5E
B7NV20, FADB_ECO7IB7N2F2, FADB_ECO81B7M649, FADB_ECO8A
C5A020, FADB_ECOBWB1XAK8, FADB_ECODHA8A6V1, FADB_ECOHS
Q0TAL0, FADB_ECOL5Q8FBI2, FADB_ECOL6B1IW61, FADB_ECOLC
P21177, FADB_ECOLIB7NFE7, FADB_ECOLUB6I4I6, FADB_ECOSE
B1LM32, FADB_ECOSMQ1R466, FADB_ECOUTA4WFX4, FADB_ENT38
Q9F0Y7, FADB_ENTCLB7LTY9, FADB_ESCF3Q5QXH7, FADB_IDILO
B5XYH0, FADB_KLEP3A6TGM4, FADB_KLEP7Q6DAP5, FADB_PECAS
Q7MZ92, FADB_PHOLLQ6LW06, FADB_PHOPRQ48GW3, FADB_PSE14
A6V382, FADB_PSEA7B7UYR6, FADB_PSEA8Q02PH8, FADB_PSEAB
Q9HZJ2, FADB_PSEAEQ1I7D4, FADB_PSEE4Q4KFC4, FADB_PSEF5
P28793, FADB_PSEFRC3K613, FADB_PSEFSA4XSM8, FADB_PSEMY
Q93Q12, FADB_PSEOLA5W6H0, FADB_PSEP1Q3K9D8, FADB_PSEPF
B0KH74, FADB_PSEPGQ88L02, FADB_PSEPKQ9AHY3, FADB_PSEPU
B1J5A5, FADB_PSEPWQ87ZB2, FADB_PSESMQ4ZRA0, FADB_PSEU2
Q4FQC6, FADB_PSYA2Q1Q8J9, FADB_PSYCKA5WH99, FADB_PSYWF
B5EZW0, FADB_SALA4Q57HM6, FADB_SALCHB5QW85, FADB_SALEP
B5RFL6, FADB_SALG2B4SZ85, FADB_SALNSQ5PKQ2, FADB_SALPA
A9MYB0, FADB_SALPBB5BIZ0, FADB_SALPKB4TNZ1, FADB_SALSV
Q8Z3C6, FADB_SALTIQ9L6L5, FADB_SALTYA8G8D1, FADB_SERP5
A1S1I8, FADB_SHEAMB8E3R3, FADB_SHEB2A3CYJ4, FADB_SHEB5
A6WHA0, FADB_SHEB8A9KU91, FADB_SHEB9Q08A39, FADB_SHEFN
B0TLB9, FADB_SHEHHA3Q8U4, FADB_SHELPQ8EKR9, FADB_SHEON
A8GYG0, FADB_SHEPAA4Y1B6, FADB_SHEPCB8CH91, FADB_SHEPW
A0KR50, FADB_SHESAA8FP63, FADB_SHESHQ0HPB7, FADB_SHESM
Q0I0T3, FADB_SHESRA1RDW6, FADB_SHESWB1KCZ3, FADB_SHEWM
B2TVJ5, FADB_SHIB3Q32A21, FADB_SHIDSQ0SZ36, FADB_SHIF8
Q83PG1, FADB_SHIFLQ3YVC1, FADB_SHISSA4VKA3, FADB_STUS1
B7VGL4, FADB_VIBA3A7N1D2, FADB_VIBC1A5F465, FADB_VIBC3
Q9KNI1, FADB_VIBCHC3LSI3, FADB_VIBCMQ87TN9, FADB_VIBPA
Q8DDK6, FADB_VIBVUQ7MQH9, FADB_VIBVYA1JIG4, FADB_YERE8
A7FDF2, FADB_YERP3Q1C2C4, FADB_YERPAB2K0Z6, FADB_YERPB
Q8ZAN0, FADB_YERPEA9R754, FADB_YERPGQ1CN99, FADB_YERPN
A4TR27, FADB_YERPPQ66FR8, FADB_YERPSB1JP63, FADB_YERPY
Q5E3U1, FADJ_ALIF1A8ADP2, FADJ_CITK8A7MH81, FADJ_CROS8
A7ZPF8, FADJ_ECO24B7UFZ8, FADJ_ECO27B7MGV7, FADJ_ECO45
B7LBJ5, FADJ_ECO55Q8XCP2, FADJ_ECO57B5YXY4, FADJ_ECO5E
B7NP24, FADJ_ECO7IB7MY16, FADJ_ECO81B7M6M2, FADJ_ECO8A
C4ZVN2, FADJ_ECOBWB1X9L4, FADJ_ECODHA8A2L0, FADJ_ECOHS
A1ADI8, FADJ_ECOK1Q0TFA6, FADJ_ECOL5Q8FFG4, FADJ_ECOL6
B1IXA5, FADJ_ECOLCP77399, FADJ_ECOLIB7N5V2, FADJ_ECOLU
B6I6Q4, FADJ_ECOSEB1LME7, FADJ_ECOSMQ1R972, FADJ_ECOUT
A4WCW6, FADJ_ENT38B7LLD0, FADJ_ESCF3Q5QXM1, FADJ_IDILO
B5XVW2, FADJ_KLEP3A6TC19, FADJ_KLEP7Q6D2L7, FADJ_PECAS
C6DAL7, FADJ_PECCPQ7N288, FADJ_PHOLLQ6LTK3, FADJ_PHOPR
B5EZR9, FADJ_SALA4Q57LW6, FADJ_SALCHB5FPN1, FADJ_SALDC
B5R3R9, FADJ_SALEPB5RCL3, FADJ_SALG2B4TCA8, FADJ_SALHS
B4SZR0, FADJ_SALNSQ5PCX6, FADJ_SALPAA9N453, FADJ_SALPB
B5BBA1, FADJ_SALPKB4TQC2, FADJ_SALSVQ8Z4Z0, FADJ_SALTI
Q8ZNA7, FADJ_SALTYA8GH86, FADJ_SERP5A1S7L6, FADJ_SHEAM
A3D684, FADJ_SHEB5A6WQ25, FADJ_SHEB8Q07ZP8, FADJ_SHEFN
B0TL21, FADJ_SHEHHA3QFP3, FADJ_SHELPQ8ECP7, FADJ_SHEON
A4Y897, FADJ_SHEPCA0KV76, FADJ_SHESAQ0HKD1, FADJ_SHESM
Q0HWN3, FADJ_SHESRA1RI92, FADJ_SHESWB2TWV4, FADJ_SHIB3
Q31YB7, FADJ_SHIBSQ32DJ4, FADJ_SHIDSQ0T2E6, FADJ_SHIF8
Q83QQ0, FADJ_SHIFLQ3YZM2, FADJ_SHISSA7MS61, FADJ_VIBC1
A5F2P2, FADJ_VIBC3Q9KT58, FADJ_VIBCHQ87MM3, FADJ_VIBPA
Q8DB47, FADJ_VIBVUQ7MIS5, FADJ_VIBVYA1JK30, FADJ_YERE8
A7FGK1, FADJ_YERP3Q1C660, FADJ_YERPAQ8ZD45, FADJ_YERPE
Q1CHK2, FADJ_YERPNA4TM82, FADJ_YERPPQ668V1, FADJ_YERPS
O32178, FADN_BACSUQ0AVM2, HBD_SYNWWO02691, HCD2_BOVIN
O18404, HCD2_DROMEQ99714, HCD2_HUMANO08756, HCD2_MOUSE
O70351, HCD2_RATP34439, HCDH1_CAEELP41938, HCDH2_CAEEL
P83589, HCDH_DEIRAQ16836, HCDH_HUMANQ61425, HCDH_MOUSE
P00348, HCDH_PIGQ9WVK7, HCDH_RATQ9NKW1, MFEA_DICDI
Q9ZPI5, MFP2_ARATHO49809, MFPA_BRANAQ39659, MFPA_CUCSA
Q8W1L6, MFP_ORYSJ

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-