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ENZYME entry: EC 1.1.1.362

Accepted Name
aklaviketone reductase.
Reaction catalysed
aklavinone + NADP(+) <=> aklaviketone + 2 H(+) + NADPH
Comment(s)
  • The enzyme is involved in the synthesis of the aklavinone aglycone, a common precursor for several anthracycline antibiotics including aclacinomycins, daunorubicin and doxorubicin.
  • The enzyme from the Gram-negative bacterium Streptomyces sp. C5 produces daunomycin.
Cross-references
BRENDA1.1.1.362
EC2PDB1.1.1.362
ExplorEnz1.1.1.362
PRIAM enzyme-specific profiles1.1.1.362
KEGG Ligand Database for Enzyme Nomenclature1.1.1.362
IUBMB Enzyme Nomenclature1.1.1.362
IntEnz1.1.1.362
MEDLINEFind literature relating to 1.1.1.362
MetaCyc1.1.1.362
Rhea expert-curated reactions1.1.1.362
UniProtKB/Swiss-Prot
Q53882, DNRE_STRS5

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