ENZYME entry: EC 1.1.1.362
| Accepted Name |
|---|
| Aklaviketone reductase.
|
| Reaction catalysed |
|---|
| Aklavinone + NADP(+) <=> aklaviketone + NADPH |
| Comment(s) |
|---|
- The enzyme is involved in the synthesis of the aklavinone aglycone,
a common precursor for several anthracycline antibiotics including
aclacinomycins, daunorubicin and doxorubicin.
- The enzyme from the Gram-negative bacterium Streptomyces sp. C5
produces daunomycin.
|
| Cross-references |
|---|
| BRENDA | 1.1.1.362 |
| EC2PDB | 1.1.1.362 |
| ExplorEnz | 1.1.1.362 |
| PRIAM enzyme-specific profiles | 1.1.1.362 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.362 |
| IUBMB Enzyme Nomenclature | 1.1.1.362 |
| IntEnz | 1.1.1.362 |
| MEDLINE | Find literature relating to 1.1.1.362 |
| MetaCyc | 1.1.1.362 |
| UniProtKB/Swiss-Prot |
|
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