ENZYME entry: EC 1.1.1.362
Accepted Name |
Aklaviketone reductase.
|
Reaction catalysed |
Aklavinone + NADP(+) <=> aklaviketone + NADPH |
Comment(s) |
- The enzyme is involved in the synthesis of the aklavinone aglycone,
a common precursor for several anthracycline antibiotics including
aclacinomycins, daunorubicin and doxorubicin.
- The enzyme from the Gram-negative bacterium Streptomyces sp. C5
produces daunomycin.
|
Cross-references |
BRENDA | 1.1.1.362 |
EC2PDB | 1.1.1.362 |
ExplorEnz | 1.1.1.362 |
PRIAM enzyme-specific profiles | 1.1.1.362 |
KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.362 |
IUBMB Enzyme Nomenclature | 1.1.1.362 |
IntEnz | 1.1.1.362 |
MEDLINE | Find literature relating to 1.1.1.362 |
MetaCyc | 1.1.1.362 |
Rhea expert-curated reactions | 1.1.1.362 |
UniProtKB/Swiss-Prot |
|
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