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ENZYME entry: EC 1.1.1.394

Accepted Name
Aurachin B dehydrogenase.
Reaction catalysed
Aurachin B + NAD(+) + H(2)O <=> 4-hydroxy-2-methyl-3-oxo-4-((2E,6E)-farnesyl)-3,4-dihydroquinoline 1-oxide + NADH
Comment(s)
  • The enzyme from the bacterium Stigmatella aurantiaca catalyzes the final step in the conversion of aurachin C to aurachin B.
  • In vivo the enzyme catalyzes the reduction of 4-hydroxy-2-methyl-3- oxo-4-((2E,6E)-farnesyl)-3,4-dihydroquinoline-1-oxide to form 2-methyl-1-oxo-4-((2E,6E)-farnesyl)-3,4-dihydroquinoline-3,4-diol (note that the reactions written above proceed from right to left), which then undergoes a spontaneous dehydration to form aurachin B.
Cross-references
BRENDA1.1.1.394
EC2PDB1.1.1.394
ExplorEnz1.1.1.394
PRIAM enzyme-specific profiles1.1.1.394
KEGG Ligand Database for Enzyme Nomenclature1.1.1.394
IUBMB Enzyme Nomenclature1.1.1.394
IntEnz1.1.1.394
MEDLINEFind literature relating to 1.1.1.394
MetaCyc1.1.1.394
UniProtKB/Swiss-Prot
H1ZZB0, AUAH_STIAU

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