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ENZYME entry: EC 1.1.1.395

Accepted Name
3-alpha-hydroxybile acid CoA 3-dehydrogenase.
Reaction catalysed
A 3-alpha-hydroxy bile acid CoA ester + NAD(+) <=> a 3-oxo bile acid CoA ester + NADH
Comment(s)
  • This bacterial enzyme is involved in the 7-dehydroxylation process associated with bile acid degradation.
  • The enzyme has very little activity with unconjugated bile acid substrates.
  • It has similar activity with choloyl-CoA, chenodeoxycholoyl-CoA, deoxycholoyl-CoA, and lithocholoyl-CoA.
  • Formerly EC 1.17.98.1.
Cross-references
BRENDA1.1.1.395
EC2PDB1.1.1.395
ExplorEnz1.1.1.395
PRIAM enzyme-specific profiles1.1.1.395
KEGG Ligand Database for Enzyme Nomenclature1.1.1.395
IUBMB Enzyme Nomenclature1.1.1.395
IntEnz1.1.1.395
MEDLINEFind literature relating to 1.1.1.395
MetaCyc1.1.1.395
UniProtKB/Swiss-Prot
P07914, BAIA1_CLOSV;  P19337, BAIA2_CLOSV;  

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