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ENZYME entry: EC 1.1.1.397

Accepted Name
beta-methylindole-3-pyruvate reductase.
Reaction catalysed
(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD(+) <=> (R)-3-(indol-3-yl)-2-oxobutanoate + H(+) + NADH
Comment(s)
The enzyme, characterized from the bacterium Streptomyces griseus, participates in the biosynthesis of indolmycin, an antibacterial drug that inhibits the bacterial EC 6.1.1.2.
Cross-references
BRENDA1.1.1.397
EC2PDB1.1.1.397
ExplorEnz1.1.1.397
PRIAM enzyme-specific profiles1.1.1.397
KEGG Ligand Database for Enzyme Nomenclature1.1.1.397
IUBMB Enzyme Nomenclature1.1.1.397
IntEnz1.1.1.397
MEDLINEFind literature relating to 1.1.1.397
MetaCyc1.1.1.397
Rhea expert-curated reactions1.1.1.397
UniProtKB/Swiss-Prot
A0A0D4BSN8, IND2_STRGR

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