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ENZYME

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ENZYME entry: EC 1.1.1.40

Accepted Name
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))
Alternative Name(s)
malic enzyme
NADP-malic enzyme
pyruvic-malic carboxylase
Reaction catalysed
  • (S)-malate + NADP(+) = CO2 + NADPH + pyruvate
  • H(+) + oxaloacetate = CO2 + pyruvate
Comment(s)
The enzyme catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate, cf. EC 1.1.1.38 and EC 1.1.1.39.
Cross-references
BRENDA1.1.1.40
EC2PDB1.1.1.40
ExplorEnz1.1.1.40
PRIAM enzyme-specific profiles1.1.1.40
KEGG Ligand Database for Enzyme Nomenclature1.1.1.40
IUBMB Enzyme Nomenclature1.1.1.40
IntEnz1.1.1.40
MEDLINEFind literature relating to 1.1.1.40
MetaCyc1.1.1.40
Rhea expert-curated reactions1.1.1.40
UniProtKB/Swiss-Prot
E1V8J1, MAEB_HALEDP76558, MAO2_ECOLIP43837, MAO2_HAEIN
O30808, MAO2_RHIMEQ9ZDF6, MAO2_RICPRQ9ZFV8, MAO2_SALTY
O34962, MAO4_BACSUP36444, MAOC_FLAPRP22178, MAOC_FLATR
P16243, MAOC_MAIZEP43279, MAOC_ORYSJP37222, MAOC_SOLLC
P78715, MAOH_NEOFRQ16798, MAON_HUMANQ8BMF3, MAON_MOUSE
O82191, MAOP1_ARATHQ9LYG3, MAOP2_ARATHQ9XGZ0, MAOP3_ARATH
Q9CA83, MAOP4_ARATHP28227, MAOX_ANAPLQ92060, MAOX_CHICK
P40927, MAOX_COLLIQ6TU48, MAOX_DICDIP48163, MAOX_HUMAN
P37223, MAOX_MESCRP06801, MAOX_MOUSEP12628, MAOX_PHAVU
Q29558, MAOX_PIGP84539, MAOX_POPEUP34105, MAOX_POPTR
P13697, MAOX_RATP51615, MAOX_VITVI

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-