ENZYME entry: EC 1.1.1.40

PURL: https://purl.expasy.org/enzyme/EC/1.1.1.40

Accepted Name

malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))

Alternative Name(s)

malic enzyme

NADP-malic enzyme

pyruvic-malic carboxylase

Reaction catalysed

(S)-malate + NADP(+) = pyruvate + CO2 + NADPH
oxaloacetate + H(+) = pyruvate + CO2

Comment(s)

The enzyme catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate, cf. EC 1.1.1.38 and EC 1.1.1.39.

Cross-references

BRENDA

1.1.1.40

EC2PDB

1.1.1.40

ExplorEnz

1.1.1.40

KEGG Ligand Database for Enzyme Nomenclature

1.1.1.40

IUBMB Enzyme Nomenclature

1.1.1.40

MEDLINE

Find literature relating to 1.1.1.40

MetaCyc

1.1.1.40

Rhea expert-curated reactions

1.1.1.40

UniProtKB/Swiss-Prot

E1V8J1, MAEB_HALED	P76558, MAO2_ECOLI	P43837, MAO2_HAEIN
O30808, MAO2_RHIME	Q9ZDF6, MAO2_RICPR	Q9ZFV8, MAO2_SALTY
O34962, MAO4_BACSU	P36444, MAOC_FLAPR	P22178, MAOC_FLATR
P16243, MAOC_MAIZE	P43279, MAOC_ORYSJ	P37222, MAOC_SOLLC
P78715, MAOH_NEOFR	Q16798, MAON_HUMAN	Q8BMF3, MAON_MOUSE
O82191, MAOP1_ARATH	Q9LYG3, MAOP2_ARATH	Q9XGZ0, MAOP3_ARATH
Q9CA83, MAOP4_ARATH	P28227, MAOX_ANAPL	Q92060, MAOX_CHICK
P40927, MAOX_COLLI	Q6TU48, MAOX_DICDI	P48163, MAOX_HUMAN
P37223, MAOX_MESCR	P06801, MAOX_MOUSE	P12628, MAOX_PHAVU
Q29558, MAOX_PIG	P84539, MAOX_POPEU	P34105, MAOX_POPTR
P13697, MAOX_RAT	P51615, MAOX_VITVI

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
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