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ENZYME entry: EC 1.1.1.40

Accepted Name
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)).
Alternative Name(s)
Malic enzyme.
NADP-malic enzyme.
Pyruvic-malic carboxylase.
Reaction catalysed
  • (S)-malate + NADP(+) <=> pyruvate + CO(2) + NADPH
  • Oxaloacetate <=> pyruvate + CO(2)
Comment(s)
The enzyme catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP(+) and divalent metal ions, and decarboxylation of oxaloacetate, cf. EC 1.1.1.38 and EC 1.1.1.39.
Cross-references
PROSITEPDOC00294
BRENDA1.1.1.40
EC2PDB1.1.1.40
ExplorEnz1.1.1.40
PRIAM enzyme-specific profiles1.1.1.40
KEGG Ligand Database for Enzyme Nomenclature1.1.1.40
IUBMB Enzyme Nomenclature1.1.1.40
IntEnz1.1.1.40
MEDLINEFind literature relating to 1.1.1.40
MetaCyc1.1.1.40
Rhea expert-curated reactions1.1.1.40
UniProtKB/Swiss-Prot
E1V8J1, MAEB_HALED;  P76558, MAO2_ECOLI;  P43837, MAO2_HAEIN;  
O30808, MAO2_RHIME;  Q9ZDF6, MAO2_RICPR;  Q9ZFV8, MAO2_SALTY;  
O34962, MAO4_BACSU;  P36444, MAOC_FLAPR;  P22178, MAOC_FLATR;  
P16243, MAOC_MAIZE;  P43279, MAOC_ORYSJ;  P37222, MAOC_SOLLC;  
P78715, MAOH_NEOFR;  Q16798, MAON_HUMAN;  Q8BMF3, MAON_MOUSE;  
O82191, MAOP1_ARATH;  Q9LYG3, MAOP2_ARATH;  Q9XGZ0, MAOP3_ARATH;  
Q9CA83, MAOP4_ARATH;  P28227, MAOX_ANAPL;  Q92060, MAOX_CHICK;  
P40927, MAOX_COLLI;  Q6TU48, MAOX_DICDI;  P48163, MAOX_HUMAN;  
P37223, MAOX_MESCR;  P06801, MAOX_MOUSE;  P12628, MAOX_PHAVU;  
Q29558, MAOX_PIG;  P84539, MAOX_POPEU;  P34105, MAOX_POPTR;  
P13697, MAOX_RAT;  P51615, MAOX_VITVI;  

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