ID 1.1.1.422 DE pseudoephedrine dehydrogenase. CA (1S,2S)-pseudoephedrine + NAD(+) = (S)-2-methylamino-1-phenylpropan-1-one CA + H(+) + NADH. CC -!- The enzyme, characterized from the bacterium Arthrobacter sp. TS-15, CC acts on a broad range of different aryl-alkyl ketones, such as CC haloketones, ketoamines, diketones, and ketoesters. CC -!- It accepts various types of aryl groups including phenyl-, pyridyl-, CC thienyl-, and furyl-rings, but the presence of an aromatic ring is CC essential for the activity. CC -!- In addition, the presence of a functional group on the alkyl chain, CC such as an amine, a halogen, or a ketone, is also crucial. CC -!- The enzyme exhibits a strict anti-Prelog enantioselectivity. CC -!- When acting on diketones, it catalyzes the reduction of only the keto CC group closest to the ring, with no further reduction to the diol. cf. CC EC 1.1.1.423. //