ID   1.1.1.428
DE   4-methylthio 2-oxobutanoate reductase (NADH).
AN   4-methylthio 2-oxobutyrate reductase.
AN   4-methylthio 2-oxobutyric acid reductase.
AN   MTOB reductase.
CA   (2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD(+) = 4-methylsulfanyl-2-
CA   oxobutanoate + H(+) + NADH.
CC   -!- The substrate of this enzyme is formed as an intermediate during
CC       L-methionine salvage from S-methyl-5'-thioadenosine, which is formed
CC       during the biosynthesis of polyamines.
CC   -!- The human enzyme also functions as a transcriptional co-regulator
CC       that downregulates the expression of many tumor-suppressor genes,
CC       thus providing a link between gene repression and the methionine
CC       salvage pathway.
CC   -!- A similar, but NADP-specific, enzyme is involved in
CC       dimethylsulfoniopropanoate biosynthesis in algae and phytoplankton.
//