ID 1.1.1.430 DE D-xylose reductase (NADH). CA xylitol + NAD(+) = D-xylose + NADH + H(+). CC -!- Xylose reductases catalyze the reduction of xylose to xylitol, CC the initial reaction in the fungal D-xylose degradation pathway. CC -!- Most of the enzymes exhibit a strict requirement for NADPH (cf. CC EC 1.1.1.431). CC -!- Some D-xylose reductases have dual cofactor specificity, though they CC still prefer NADPH to NADH (cf. EC 1.1.1.307). CC -!- The enzyme from Candida parapsilosis is a rare example of a xylose CC reductase that significantly prefers NADH, with Km and Vmax values CC for NADH being 10-fold lower and 10-fold higher, respectively, than CC for NADPH. DR P38715, GRE3_YEAST ; C5FFQ7, XYL1_ARTOC ; A1CRI1, XYL1_ASPCL ; DR A1D4E3, XYL1_ASPF1 ; B0XNR0, XYL1_ASPFC ; B8N195, XYL1_ASPFN ; DR Q4WJT9, XYL1_ASPFU ; A2Q8B5, XYL1_ASPNC ; Q9P8R5, XYL1_ASPNG ; DR Q2UKD0, XYL1_ASPOR ; Q0CUL0, XYL1_ASPTN ; Q8X195, XYL1_CANBO ; DR Q6Y0Z3, XYL1_CANPA ; O74237, XYL1_CANTE ; O13283, XYL1_CANTR ; DR Q5BGA7, XYL1_EMENI ; P49378, XYL1_KLULA ; P78736, XYL1_PACTA ; DR O94735, XYL1_PICGU ; P31867, XYL1_PICST ; Q9P430, XYL1_SCHSH ; DR Q876L8, XYL1_TRIRF ; P87039, XYL2_CANTR ; //