ID 1.1.1.431 DE D-xylose reductase (NADPH). CA NADP(+) + xylitol = D-xylose + H(+) + NADPH. CC -!- Xylose reductases catalyze the reduction of xylose to xylitol, CC the initial reaction in the fungal D-xylose degradation pathway. CC -!- Most of the enzymes exhibit a strict requirement for NADPH (e.g. the CC enzymes from Saccharomyces cerevisiae, Aspergillus niger, Trichoderma CC reesei, Candida tropicalis, Saitozyma flava, and Candida intermedia). CC -!- Some D-xylose reductases have dual cofactor specificity, though they CC still prefer NADPH to NADH (cf. EC 1.1.1.307). CC -!- Very rarely the enzyme prefers NADH (cf. EC 1.1.1.430). //