ENZYME entry: EC 1.1.1.439
| Accepted Name | ||
|---|---|---|
| 17-dehydrostemmadenine reductase | ||
| Reaction catalysed | ||
| 15alpha-stemmadenine + NADP(+) = 17-dehydrostemmadenine + NADPH + 2 H(+) | ||
| Comment(s) | ||
| The enzyme, characterized from the plant Catharanthus roseus (Madagascar periwinkle), participates in a biosynthetic pathway that leads to production of the bisindole alkaloid compounds vinblastine and vincristine, which are used as anticancer drugs. | ||
| Cross-references | ||
| BRENDA | 1.1.1.439 | |
| EC2PDB | 1.1.1.439 | |
| ExplorEnz | 1.1.1.439 | |
| PRIAM enzyme-specific profiles | 1.1.1.439 | |
| KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.439 | |
| IUBMB Enzyme Nomenclature | 1.1.1.439 | |
| IntEnz | 1.1.1.439 | |
| MEDLINE | Find literature relating to 1.1.1.439 | |
| MetaCyc | 1.1.1.439 | |
| Rhea expert-curated reactions | 1.1.1.439 | |
| UniProtKB/Swiss-Prot |
| |
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