ID   1.1.1.441
DE   polyprenol dehydrogenase [NAD(P)H].
AN   dolichal reductase.
CA   (1) a di-trans,poly-cis-polyprenol + NAD(+) = a di-trans,poly-
CA   cis-polyprenal + NADH + H(+).
CA   (2) a di-trans,poly-cis-polyprenol + NADP(+) = a di-trans,poly-
CA   cis-polyprenal + NADPH + H(+).
CA   (3) a di-trans,poly-cis-dolichol + NADP(+) = a di-trans,poly-cis-dolichal
CA   + NADPH + H(+).
CA   (4) a di-trans,poly-cis-dolichol + NAD(+) = a di-trans,poly-cis-dolichal
CA   + NADH + H(+).
CC   -!- The enzyme, present in all eukaryotes, catalyzes the dehydrogenation
CC       of ditrans,polycis-polyprenol and the reduction of dolichal as part
CC       of the pathway that converts ditrans,polycis-polyprenol to dolichol
CC       (cf. 1.3.1.94).
CC   -!- The enzyme works equally well with NAD(+) and NADP(+), but due to the
CC       cellular ratios of NAD(+)/NADH and NADP(+)/NADPH, the enzyme
CC       catalyzes the oxidation of of polyprenol using NAD(+) as the electron
CC       acceptor, and the reduction of dolichal using NADPH as the electron
CC       donor.
DR   B8A5W4, DHRSX_DANRE;  Q8N5I4, DHRSX_HUMAN;  Q8VBZ0, DHRSX_MOUSE;
//