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ENZYME entry: EC 1.1.1.50

Accepted Name
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific).
Alternative Name(s)
3alpha-HSD.
3alpha-hydroxysteroid 3-dehydrogenase (B-specific).
3alpha-hydroxysteroid dehydrogenase (B-specific).
hydroxyprostaglandin dehydrogenase.
Reaction catalysed
  • a 3alpha-hydroxysteroid + NAD(+) <=> a 3-oxosteroid + H(+) + NADH
  • a 3alpha-hydroxysteroid + NADP(+) <=> a 3-oxosteroid + H(+) + NADPH
Comment(s)
  • The enzyme acts on androsterone and other 3alpha-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin.
  • Si-specific with respect to NAD(+) or NADP(+) (cf. EC 1.1.1.213).
Cross-references
BRENDA1.1.1.50
EC2PDB1.1.1.50
ExplorEnz1.1.1.50
PRIAM enzyme-specific profiles1.1.1.50
KEGG Ligand Database for Enzyme Nomenclature1.1.1.50
IUBMB Enzyme Nomenclature1.1.1.50
IntEnz1.1.1.50
MEDLINEFind literature relating to 1.1.1.50
MetaCyc1.1.1.50
Rhea expert-curated reactions1.1.1.50
UniProtKB/Swiss-Prot
P80702, DIDH_COMTE;  P80701, DIDH_PSESP;  P23457, DIDH_RAT;  

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