ID 1.1.1.53 DE 3alpha(or 20beta)-hydroxysteroid dehydrogenase. AN (R)-20-hydroxysteroid dehydrogenase. AN cortisone reductase. CA androstan-3alpha,17beta-diol + NAD(+) = 17beta-hydroxyandrostanone + H(+) CA + NADH. CC -!- The 3alpha-hydroxy group or 20beta-hydroxy group of pregnane and CC androstane steroids can act as donor. DR Q04828, AK1C1_HUMAN; Q95JH7, AK1C1_MACFA; Q95JH6, AK1C1_MACFU; DR Q5REQ0, AK1C1_PONAB; P52895, AK1C2_HUMAN; P42330, AK1C3_HUMAN; DR Q5R7C9, AK1C3_PONAB; P17516, AK1C4_HUMAN; Q95JH5, AK1C4_MACFA; DR Q95JH4, AK1C4_MACFU; Q8HYR6, DHRS9_BOVIN; Q9BPW9, DHRS9_HUMAN; DR Q58NB6, DHRS9_MOUSE; Q8VD48, DHRS9_RAT ; Q3T001, H17B6_BOVIN; DR O14756, H17B6_HUMAN; Q9R092, H17B6_MOUSE; O54753, H17B6_RAT ; DR O02691, HCD2_BOVIN ; O18404, HCD2_DROME ; Q99714, HCD2_HUMAN ; DR O08756, HCD2_MOUSE ; O70351, HCD2_RAT ; P69166, HSD_MYCBO ; DR P9WGT0, HSD_MYCTO ; P9WGT1, HSD_MYCTU ; P19992, HSD_STREX ; DR O75452, RDH16_HUMAN; O54909, RDH16_MOUSE; P50170, RDH16_RAT ; DR Q27979, RDH5_BOVIN ; Q92781, RDH5_HUMAN ; O55240, RDH5_MOUSE ; //