ID   1.1.1.62
DE   17beta-estradiol 17-dehydrogenase.
AN   17beta-estradiol dehydrogenase.
AN   17beta-HSD.
AN   17beta-hydroxysteroid dehydrogenase.
AN   20alpha-hydroxysteroid dehydrogenase.
AN   estrogen 17-oxidoreductase.
CA   (1) 17beta-estradiol + NAD(+) = estrone + NADH + H(+).
CA   (2) 17beta-estradiol + NADP(+) = estrone + NADPH + H(+).
CC   -!- The enzyme oxidizes or reduces the hydroxy/keto group on C17 of
CC       estrogens and androgens in mammals and regulates the biological
CC       potency of these steroids.
CC   -!- The mammalian enzyme is bifunctional and also catalyzes EC 1.1.1.270.
CC   -!- The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related
CC       compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, it is
CC       Si-specific with respect to NAD(P)(+).
DR   Q04828, AK1C1_HUMAN;  Q95JH7, AK1C1_MACFA;  Q95JH6, AK1C1_MACFU;
DR   Q5REQ0, AK1C1_PONAB;  P52895, AK1C2_HUMAN;  P05980, AK1C3_BOVIN;
DR   P42330, AK1C3_HUMAN;  Q5R7C9, AK1C3_PONAB;  P52898, AK1C4_BOVIN;
DR   P17516, AK1C4_HUMAN;  Q95JH5, AK1C4_MACFA;  Q95JH4, AK1C4_MACFU;
DR   Q6P3L6, DH12A_DANRE;  Q5XG41, DH12A_XENLA;  Q6QA33, DH12B_DANRE;
DR   Q8AVY8, DH12B_XENLA;  Q8NBQ5, DHB11_HUMAN;  Q4JK73, DHB11_MACFA;
DR   Q9EQ06, DHB11_MOUSE;  Q5NVG2, DHB11_PONAB;  Q6AYS8, DHB11_RAT  ;
DR   O57314, DHB12_ANAPL;  Q5E9H7, DHB12_BOVIN;  Q53GQ0, DHB12_HUMAN;
DR   Q4R5G7, DHB12_MACFA;  O70503, DHB12_MOUSE;  Q6P7R8, DHB12_RAT  ;
DR   Q28IU1, DHB12_XENTR;  Q7Z5P4, DHB13_HUMAN;  Q8VCR2, DHB13_MOUSE;
DR   Q5M875, DHB13_RAT  ;  P14061, DHB1_HUMAN ;  P51656, DHB1_MOUSE ;
DR   Q1WNP0, DHB1_PANTR ;  P51657, DHB1_RAT   ;  P37059, DHB2_HUMAN ;
DR   P51658, DHB2_MOUSE ;  Q62730, DHB2_RAT   ;  P37058, DHB3_HUMAN ;
DR   P70385, DHB3_MOUSE ;  O54939, DHB3_RAT   ;  P56937, DHB7_HUMAN ;
DR   O88736, DHB7_MOUSE ;  Q62904, DHB7_RAT   ;  Q9GME3, DHB8_CALJA ;
DR   Q5TJF5, DHB8_CANLF ;  Q92506, DHB8_HUMAN ;  P50171, DHB8_MOUSE ;
DR   Q9XT00, DHB8_PIG   ;  Q6MGB5, DHB8_RAT   ;  Q3ZBV9, DHR11_BOVIN;
DR   Q71R50, DHR11_CHICK;  Q6UWP2, DHR11_HUMAN;  Q3U0B3, DHR11_MOUSE;
DR   Q3T001, H17B6_BOVIN;  O14756, H17B6_HUMAN;  Q9R092, H17B6_MOUSE;
DR   O54753, H17B6_RAT  ;  O02691, HCD2_BOVIN ;  O18404, HCD2_DROME ;
DR   Q99714, HCD2_HUMAN ;  O08756, HCD2_MOUSE ;  O70351, HCD2_RAT   ;
DR   Q93W57, HSDA_SESIN ;  Q8LKV5, HSDB_SESIN ;  A0A140FAN3, HSD_PINMS  ;
//