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ENZYME entry: EC 1.1.1.87

Accepted Name
Homoisocitrate dehydrogenase.
Alternative Name(s)
(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD(+) oxidoreductase (decarboxylating).
2-hydroxy-3-carboxyadipate dehydrogenase.
3-carboxy-2-hydroxyadipate dehydrogenase.
3-carboxy-2-hydroxyadipate:NAD(+) oxidoreductase (decarboxylating).
Homoisocitric dehydrogenase.
Reaction catalysed
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD(+) <=> 2-oxoadipate + CO(2) + NADH
Comment(s)
  • Forms part of the lysine biosynthesis pathway in fungi.
  • Formerly EC 1.1.1.155.
Cross-references
PROSITEPDOC00389
BRENDA1.1.1.87
EC2PDB1.1.1.87
ExplorEnz1.1.1.87
PRIAM enzyme-specific profiles1.1.1.87
KEGG Ligand Database for Enzyme Nomenclature1.1.1.87
IUBMB Enzyme Nomenclature1.1.1.87
IntEnz1.1.1.87
MEDLINEFind literature relating to 1.1.1.87
MetaCyc1.1.1.87
Rhea expert-curated reactions1.1.1.87
UniProtKB/Swiss-Prot
Q58991, AKSF_METJA;  Q72IW9, HICDH_THET2;  Q5SIJ1, HICDH_THET8;  
O14104, LYS12_SCHPO;  P40495, LYS12_YEAST;  

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