ENZYME entry: EC 1.1.1.n4
| Accepted Name |
|---|
| (-)-trans-carveol dehydrogenase.
|
| Alternative Name(s) |
|---|
| (4R,6S)-carveol dehydrogenase. |
| Carveol dehydrogenase. |
| CDH. |
| Reaction catalysed |
|---|
- (-)-(4R,6S)-trans-carveol + NAD(+) <=> (-)-(4R)-carvone + NADH
- (+)-(4S,6S)-cis-carveol + NAD(+) <=> (+)-(4S)-carvone + NADH
|
| Comment(s) |
|---|
- Catalyzes the oxidation of carveol to carvone, with a strong
stereoselectivity since it efficiently converts only the (6S)-
stereoisomers, of which (-)-(4R,6S)-trans-carveol is the better
substrate.
- Displays a broad substrate specificity with a preference for
substituted cyclohexanols, and does not catalyze the oxidation of
primary or short chain aliphatic secondary alcohols.
- Is also able, albeit more slowly, to oxidize limonene-1,2-diol into
1-hydroxy-2-oxolimonene.
|
| Cross-references |
|---|
| UniProtKB/Swiss-Prot |
|
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