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ENZYME entry: EC 1.1.2.8

Accepted Name
alcohol dehydrogenase (cytochrome c).
Reaction catalysed
a primary alcohol + 2 Fe(III)-[cytochrome c] <=> an aldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)
Comment(s)
  • A periplasmic PQQ-containing quinoprotein.
  • Occurs in Pseudomonas and Rhodopseudomonas.
  • The enzyme from Pseudomonas aeruginosa uses a specific inducible cytochrome c550 as electron acceptor.
  • Acts on a wide range of primary and secondary alcohols, but not methanol.
  • It has a homodimeric structure (contrasting with the heterotetrameric structure of EC 1.1.2.7, methanol dehydrogenase (cytochrome c)).
  • It is routinely assayed with phenazine methosulfate as electron acceptor.
  • Activity is stimulated by ammonia or amines.
  • Like all other quinoprotein alcohol dehydrogenases it has an 8-bladed 'propeller' structure, a calcium ion bound to the PQQ in the active site and an unusual disulfide ring structure in close proximity to the PQQ.
  • Formerly EC 1.1.99.8.
Cross-references
BRENDA1.1.2.8
EC2PDB1.1.2.8
ExplorEnz1.1.2.8
PRIAM enzyme-specific profiles1.1.2.8
KEGG Ligand Database for Enzyme Nomenclature1.1.2.8
IUBMB Enzyme Nomenclature1.1.2.8
IntEnz1.1.2.8
MEDLINEFind literature relating to 1.1.2.8
MetaCyc1.1.2.8
Rhea expert-curated reactions1.1.2.8
UniProtKB/Swiss-Prot
Q9Z4J7, QEDH_PSEAE;  A8R3S4, QEDH_PSEPU;  

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