Home  |  Contact

ENZYME entry: EC 1.1.2.8

Accepted Name
Alcohol dehydrogenase (cytochrome c).
Reaction catalysed
A primary alcohol + 2 cytochrome c <=> an aldehyde + 2 reduced cytochrome c + 2 H(+)
Cofactor(s)
Pyrroloquinoline quinone.
Comment(s)
  • A periplasmic PQQ-containing quinoprotein.
  • Occurs in Pseudomonas and Rhodopseudomonas.
  • The enzyme from Pseudomonas aeruginosa uses a specific inducible cytochrome c(550) as electron acceptor.
  • Acts on a wide range of primary and secondary alcohols, but not methanol.
  • It has a homodimeric structure (contrasting with the heterotetrameric structure of EC 1.1.2.7, methanol dehydrogenase (cytochrome c)).
  • It is routinely assayed with phenazine methosulfate as electron acceptor.
  • Activity is stimulated by ammonia or amines.
  • Like all other quinoprotein alcohol dehydrogenases it has an 8-bladed 'propeller' structure, a calcium ion bound to the PQQ in the active site and an unusual disulfide ring structure in close proximity to the PQQ.
  • Formerly EC 1.1.99.8.
Cross-references
BRENDA1.1.2.8
EC2PDB1.1.2.8
ExplorEnz1.1.2.8
PRIAM enzyme-specific profiles1.1.2.8
KEGG Ligand Database for Enzyme Nomenclature1.1.2.8
IUBMB Enzyme Nomenclature1.1.2.8
IntEnz1.1.2.8
MEDLINEFind literature relating to 1.1.2.8
MetaCyc1.1.2.8
UniProtKB/Swiss-Prot
Q9Z4J7, EXAA_PSEAE;  A8R3S4, QEDH_PSEPU;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-