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ENZYME entry: EC 1.1.3.15

Accepted Name
(S)-2-hydroxy-acid oxidase.
Alternative Name(s)
Glycolate oxidase.
Hydroxy-acid oxidase A.
Hydroxy-acid oxidase B.
Reaction catalysed
(S)-2-hydroxy acid + O(2) <=> 2-oxo acid + H(2)O(2)
Cofactor(s)
FMN.
Comment(s)
  • Exists as two major isoenzymes; the A form preferentially oxidizes short-chain aliphatic hydroxy acids; the B form preferentially oxidizes long-chain and aromatic hydroxy acids.
  • The rat isoenzyme B also acts as EC 1.4.3.2.
  • Formerly EC 1.1.3.1.
Cross-references
PROSITEPDOC00482
BRENDA1.1.3.15
EC2PDB1.1.3.15
ExplorEnz1.1.3.15
PRIAM enzyme-specific profiles1.1.3.15
KEGG Ligand Database for Enzyme Nomenclature1.1.3.15
IUBMB Enzyme Nomenclature1.1.3.15
IntEnz1.1.3.15
MEDLINEFind literature relating to 1.1.3.15
MetaCyc1.1.3.15
Rhea expert-curated reactions1.1.3.15
UniProtKB/Swiss-Prot
Q9LRR9, GLO1_ARATH;  B8AKX6, GLO1_ORYSI;  Q10CE4, GLO1_ORYSJ;  
Q9LRS0, GLO2_ARATH;  Q01KC2, GLO2_ORYSI;  Q7XPR4, GLO2_ORYSJ;  
B8AUI3, GLO3_ORYSI;  Q7FAS1, GLO3_ORYSJ;  O49506, GLO5_ARATH;  
B8B7C5, GLO5_ORYSI;  Q6YT73, GLO5_ORYSJ;  A0A3L6E0R4, GOX1_MAIZE;  
P05414, GOX_SPIOL;  Q9LJH5, HAOX1_ARATH;  Q9UJM8, HAOX1_HUMAN;  
Q9WU19, HAOX1_MOUSE;  B0BNF9, HAOX1_RAT;  Q24JJ8, HAOX2_ARATH;  
Q3ZBW2, HAOX2_BOVIN;  Q9NYQ3, HAOX2_HUMAN;  Q9NYQ2, HAOX2_MOUSE;  
Q07523, HAOX2_RAT;  Q54E41, HAOX_DICDI;  B8B8K5, HAOX_ORYSI;  
Q8H3I4, HAOX_ORYSJ;  F4G5A4, LOX_ALIDK;  A0A5N1I561, LOX_LACJE;  
B1HZY7, LOX_LYSSC;  B7RR92, LOX_ROSS0;  

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