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ENZYME entry: EC 1.1.3.6

Accepted Name
cholesterol oxidase.
Alternative Name(s)
cholesterol-O2 oxidoreductase.
Reaction catalysed
cholesterol + O2 <=> cholest-5-en-3-one + H2O2
Comment(s)
  • Cholesterol oxidases are secreted bacterial bifunctional enzymes that catalyze the first two steps in the degradation of cholesterol.
  • The enzyme catalyzes the oxidation of the 3beta-hydroxyl group to a keto group, and the isomerization of the double bond in the oxidized steroid ring system from the Delta(5) position to the Delta(6) position (cf. EC 5.3.3.1).
Cross-references
BRENDA1.1.3.6
EC2PDB1.1.3.6
ExplorEnz1.1.3.6
PRIAM enzyme-specific profiles1.1.3.6
KEGG Ligand Database for Enzyme Nomenclature1.1.3.6
IUBMB Enzyme Nomenclature1.1.3.6
IntEnz1.1.3.6
MEDLINEFind literature relating to 1.1.3.6
MetaCyc1.1.3.6
Rhea expert-curated reactions1.1.3.6
UniProtKB/Swiss-Prot
P22637, CHOD_BREST;  P9WMV8, CHOD_MYCTO;  P9WMV9, CHOD_MYCTU;  
P12676, CHOD_STRS0;  

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