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ENZYME

ENZYME entry: EC 1.1.5.2

Accepted Name
quinoprotein glucose dehydrogenase (PQQ, quinone)
Alternative Name(s)
D-glucose:(pyrroloquinoline-quinone) 1-oxidoreductase
glucose dehydrogenase (PQQ-dependent)
glucose dehydrogenase (pyrroloquinoline-quinone)
quinoprotein D-glucose dehydrogenase
Reaction catalysed
a ubiquinone + D-glucose <=> a ubiquinol + D-glucono-1,5-lactone
Comment(s)
  • Integral membrane protein containing PQQ as cofactor.
  • It also contains bound ubiquinone and Mg(2+) or Ca(2+).
  • Electron acceptor is membrane ubiquinone but usually assayed with phenazine methosulfate.
  • Like in all other quinoprotein alcohol dehydrogenases the catalytic domain has an 8-bladed 'propeller' structure.
  • It occurs in a wide range of bacteria.
  • Catalyzes a direct oxidation of the pyranose form of D-glucose to the lactone and thence to D-gluconate in the periplasm.
  • Oxidizes other monosaccharides including the pyranose forms of pentoses.
  • Formerly EC 1.1.99.17.
Cross-references
BRENDA1.1.5.2
EC2PDB1.1.5.2
ExplorEnz1.1.5.2
PRIAM enzyme-specific profiles1.1.5.2
KEGG Ligand Database for Enzyme Nomenclature1.1.5.2
IUBMB Enzyme Nomenclature1.1.5.2
IntEnz1.1.5.2
MEDLINEFind literature relating to 1.1.5.2
MetaCyc1.1.5.2
Rhea expert-curated reactions1.1.5.2
UniProtKB/Swiss-Prot
P13650, DHGB_ACICAP15877, DHG_ECOLIP27175, DHG_GLUOX

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