ENZYME

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.1.5.2

Accepted Name

Quinoprotein glucose dehydrogenase (PQQ, quinone).

Alternative Name(s)

D-glucose:(pyrroloquinoline-quinone) 1-oxidoreductase.

Glucose dehydrogenase (PQQ-dependent).

Glucose dehydrogenase (pyrroloquinoline-quinone).

Quinoprotein D-glucose dehydrogenase.

Reaction catalysed

D-glucose + ubiquinone <=> D-glucono-1,5-lactone + ubiquinol

Cofactor(s)

Ca(2+) or Mg(2+); Pyrroloquinoline quinone.

Comment(s)

Integral membrane protein containing PQQ as prosthetic group.
It also contains bound ubiquinone and Mg(2+) or Ca(2+).
Electron acceptor is membrane ubiquinone but usually assayed with phenazine methosulfate.
Like in all other quinoprotein alcohol dehydrogenases the catalytic domain has an 8-bladed 'propeller' structure.
It occurs in a wide range of bacteria.
Catalyzes a direct oxidation of the pyranose form of D-glucose to the lactone and thence to D-gluconate in the periplasm.
Oxidizes other monosaccharides including the pyranose forms of pentoses.
Formerly EC 1.1.99.17.

Cross-references

PROSITE

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature