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ENZYME

ENZYME entry: EC 1.1.99.18

Accepted Name
cellobiose dehydrogenase (acceptor)
Alternative Name(s)
CBOR
CDH
cellobiose dehydrogenase
cellobiose dehydrogenase (quinone)
cellobiose oxidase
cellobiose oxidoreductase
cellobiose-quinone oxidoreductase
Reaction catalysed
A + D-cellobiose <=> AH2 + D-cellobiono-1,5-lactone
Comment(s)
  • Also acts, more slowly, on cello-oligosaccharides, lactose and D-glucosyl-1,4-beta-D-mannose.
  • The enzyme from the white rot fungus Phanerochaete chrysosporium is unusual in having two redoxin domains, one containing a flavin and the other a protoheme group.
  • It transfers reducing equivalents from cellobiose to two types of redox acceptor: two-electron oxidants, including redox dyes, benzoquinones, and molecular oxygen, and one-electron oxidants, including semiquinone species, iron(II) complexes, and the model acceptor cytochrome c.
  • 2,6-dichloroindophenol can act as acceptor in vitro.
  • Formerly EC 1.1.3.25.
Cross-references
BRENDA1.1.99.18
EC2PDB1.1.99.18
ExplorEnz1.1.99.18
PRIAM enzyme-specific profiles1.1.99.18
KEGG Ligand Database for Enzyme Nomenclature1.1.99.18
IUBMB Enzyme Nomenclature1.1.99.18
IntEnz1.1.99.18
MEDLINEFind literature relating to 1.1.99.18
MetaCyc1.1.99.18
Rhea expert-curated reactions1.1.99.18
UniProtKB/Swiss-Prot
Q01738, CDH_PHACH

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