ENZYME

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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.1.99.27

Accepted Name
(R)-pantolactone dehydrogenase (flavin).
Alternative Name(s)
(R)-pantoyllactone dehydrogenase (flavin).
2-dehydropantolactone reductase (flavin).
2-dehydropantoyl-lactone reductase (flavin).
Reaction catalysed
(R)-pantolactone + acceptor <=> 2-dehydropantolactone + reduced acceptor
Cofactor(s)
FMN.
Comment(s)
High specificity for (R)-pantolactone. Phenazine methosulfate (PMS) can act as acceptor. The enzyme has been studied in Nocardia asteroides and shown to be membrane-bound and induced by 1,2-propanediol.
Cross-references
BRENDA	1.1.99.27
EC2PDB	1.1.99.27
ExplorEnz	1.1.99.27
PRIAM enzyme-specific profiles	1.1.99.27
KEGG Ligand Database for Enzyme Nomenclature	1.1.99.27
IUBMB Enzyme Nomenclature	1.1.99.27
IntEnz	1.1.99.27
MEDLINE	Find literature relating to 1.1.99.27
MetaCyc	1.1.99.27