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ENZYME entry: EC 1.1.99.30

Accepted Name
2-oxo-acid reductase.
Alternative Name(s)
(2R)-hydroxycarboxylate-viologen-oxidoreductase.
2-oxoacid reductase.
HVOR.
Reaction catalysed
A (2R)-hydroxy-carboxylate + acceptor <=> a 2-oxo-carboxylate + reduced acceptor
Cofactor(s)
Iron-sulfur; Mo-molybdopterin.
Comment(s)
  • Has broad substrate specificity, with 2-oxo-monocarboxylates and 2-oxo-dicarboxylates acting as substrates.
  • Branching in a substrate at the C-3 position results in loss of activity.
  • The enzyme from Proteus sp. is inactivated by oxygen.
Cross-references
BRENDA1.1.99.30
EC2PDB1.1.99.30
ExplorEnz1.1.99.30
PRIAM enzyme-specific profiles1.1.99.30
KEGG Ligand Database for Enzyme Nomenclature1.1.99.30
IUBMB Enzyme Nomenclature1.1.99.30
IntEnz1.1.99.30
MEDLINEFind literature relating to 1.1.99.30
MetaCyc1.1.99.30
Rhea expert-curated reactions1.1.99.30
UniProtKB/Swiss-Prot
Q9R4Y1, HVOR_PROVU

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