ID   1.1.99.31
DE   (S)-mandelate dehydrogenase.
AN   L(+)-mandelate dehydrogenase.
AN   MDH.
CA   (S)-mandelate + A = AH2 + phenylglyoxylate.
CC   -!- While all enzymes of this family oxidize the (S)-enantiomer of an
CC       alpha-hydroxy acid to an alpha-oxo acid, the ultimate oxidant
CC       (oxygen, intramolecular heme or some other acceptor) depends on the
CC       particular enzyme.
CC   -!- Transfers the electron pair from FMNH2 to a component of the electron
CC       transport chain, most probably ubiquinone.
CC   -!- It is part of a metabolic pathway in Pseudomonads that allows these
CC       organisms to utilize mandelic acid, derivatized from the common soil
CC       metabolite amygdalin, as the sole source of carbon and energy.
CC   -!- Has a large active-site pocket and preferentially binds substrates
CC       with longer sidechains, e.g. 2-hydroxyoctanoate rather than
CC       2-hydroxybutyrate.
CC   -!- It also prefers substrates that, like (S)-mandelate, have beta
CC       unsaturation, e.g. (indol-3-yl)glycolate compared with (indol-3-
CC       yl)lactate.
CC   -!- Esters of mandelate, such as methyl (S)-mandelate, are also
CC       substrates.
DR   P32953, CYBL_RHOGR ;  P20932, MDLB_PSEPU ;
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